Studies on the Interaction for Baicalein and Baicalin with Human Serum Albumin by Spectroscopic Methods

Abstract

Abstract: The fluorescence, ultraviolet-visible and surface-enhanced Raman scattering spectroscopy were applied to study the interaction between baicalein/baicalin and human serum albumin, as the subsequent consequence, the information of intermolecular adsorption and surface-enhanced Raman Scattering spectroscopy, the normal crientation were obtained. By the comparison of norml Ramn and onformation of baicalein and baicalin were confirmed. Besides that, we also studied the orientated difference between baicalein and baicalin after their combining to human serum albumin. In addition, the state of freedom ions on the binding of baialein/baicalin and human serum were also investigated in physiological conditions, which is the most accessible work of simulation in vitro.

Key words: Baicalein, Baicalin, Human serum albumin, Fluorescence spectrum, Ultraviolet-visible spectrum, Surface enhanced Raman scattering spectroscopy

TrendMD:

ZHANG Wei, ZHAO Yu, BAI Xue-Yuan, HUI Ge, ZHAO Da-Qing, ZHAO Bing*. Studies on the Interaction for Baicalein and Baicalin with Human Serum Albumin by Spectroscopic Methods[J]. Chem. J. Chinese Universities, 2010, 31(9): 1834.

References

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