Syntheses and Anticoagulant Action of Rare Earth Ternary omplexes with Warfarin and Ferulic Acid†

doi:10.7503/cjcu20150015

Abstract

Abstract:

Four ternary rare earth complexes of warfarin(W) and freulic acid(FA), RE(C₁₉H₁₅O₄)₂·(C₁₀H₉O₄)·2H₂O(RE=La, Nd, Ce, Eu), were obtained via the reaction of ferulic acid and warfarin with rare earth ions in the ethanol solution by solvent-thermal method. The composition of these complexes was characterized by infrared(IR) spectrometry, thermogravimetric-differential thermal analysis(TG-DTA), elemental analysis, X-ray diffraction(XRD) analysis and nuclear magnetic resonance(NMR) spectrometry. Meanwhile, the anticoagulant properties of warfarin, ferulic acid and their complexes were tested by coagulation time(CT), recalcification time(RT), activated partial thromboplastin time(APTT) and prothrombin time(PT) in physiological conditions. The results show that the four ternary rare earth complexes all have better anticoagulant action than the binary complexes of ferulic acid and warfarin in related anticoagulant experiments. The four ternary rare earth complexes could reduce the fluorescence intensity and enhance the UV intensity of human serum albumin(HSA).

Key words: Rare earth, Warfarin, Ferulic acid, Anticoagulant property, Human serum albumin(HSA)

CLC Number:

0614.33

TrendMD:

YANG Meiling, QIN Dongdong, SONG Yumin. Syntheses and Anticoagulant Action of Rare Earth Ternary omplexes with Warfarin and Ferulic Acid^†[J]. Chem. J. Chinese Universities, 2015, 36(5): 821.

Figures/Tables 15

References 28

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Complex	Found(Calcd.)(%)			Λ/(S·cm²·mol^-1)
Complex	C		H	RE
FA-W-La	49.96(49.66)	5.30(5.10)	14.93(14.15)	29.3
FA-W-Ce	46.88(46.43)	5.53(5.02)	15.68(14.23)	27.4
FA-W-Nd	46.01(46.44)	5.75(5.03)	16.04(14.58)	19.6
FA-W-Eu	49.20(49.43)	4.11(4.53)	17.36(15.27)	18.4

Complex	Found(Calcd.)(%)			Λ/(S·cm²·mol^-1)
Complex	C		H	RE
FA-W-La	49.96(49.66)	5.30(5.10)	14.93(14.15)	29.3
FA-W-Ce	46.88(46.43)	5.53(5.02)	15.68(14.23)	27.4
FA-W-Nd	46.01(46.44)	5.75(5.03)	16.04(14.58)	19.6
FA-W-Eu	49.20(49.43)	4.11(4.53)	17.36(15.27)	18.4

Parameter	W-FA-La	W-FA-Nd	W-FA-Ce	W-FA-Eu
β	0.9624	0.9790	0.9644	0.9819
b^1/2	0.1371	0.1025	0.1334	0.0951
δ	3.9	2.1	3.6	1.8

Parameter	W-FA-La	W-FA-Nd	W-FA-Ce	W-FA-Eu
β	0.9624	0.9790	0.9644	0.9819
b^1/2	0.1371	0.1025	0.1334	0.0951
δ	3.9	2.1	3.6	1.8

Compound	Concentration/(mol·L^-1)	CT/min	P
Blank	0	4	<0.05
FA	2.0×10^-4	6	<0.05
W	2.0×10^-4	7	<0.05
W-La^a	2.5×10^-4	11.0	<0.05
W-Nd^a	2.5×10^-4	13.0	<0.05
W-Eu^a	2.5×10^-4	9.5	<0.05
W-Y^a	2.5×10^-4	8.8	<0.05
FA-Nd^b	2.5×10^-4	13.4	<0.05
FA-Ce^b	2.5×10^-4	11.3	<0.05
FA-Eu^b	2.5×10^-4	11.9	<0.05
W-FA-La	2.0×10^-4	25	<0.05
W-FA-Nd	2.0×10^-4	44	<0.05
W-FA-Ce	2.0×10^-4	40	<0.05
W-FA-Eu	2.0×10^-4	42	<0.05