Two tetranuclear compounds, Mn4(T4A)2 (1) and Mn4(T4A)2 (DMF)2(2) (T4A = thiacalix[4]arene), were synthesized via the solvothermal reaction of manganese (II) acetic and thiacalix[4]arene with different solvents. Single-crystal analysis reveals that compound 1 with a two-dimensional Kagomé lattice was obtained with the mixed CHCl3/CH3OH solvent, while the interpenetrated 2D compound 2 was synthesized in the mixed DMF/CH3OH solution. Porous compound 1 has some large solvent accessible voids while compound 2 has an impacted extended structure.