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Research Progress and Mechanism of cGAS-STING Pathway in Tumor Immunotherapy WANG Shihao, SHI Wanrui, LIU Yi, ZHANG Hao Chem. J. Chinese Universities    2025, 46 (1): 20240241-.   DOI: 10.7503/cjcu20240241 Abstract （1292）   HTML （14）    PDF（pc） （9509KB）（306）       Knowledge map    Save The cyclic guanosine monophosphate-adenosine monophosphate（GMP-AMP） synthase（cGAS protein）- stimulator of interferon genes（STING protein)（cGAS-STING） signaling pathway is a crucial pathway for recognizing abnormal DNA in the cytoplasm and activating the innate immune response system. After recognizing abnormal DNA in the cytoplasm， cGAS protein can catalyze the synthesis of cyclic guanosine diphosphate adenosine（cyclic GMP-AMP， cGAMP） from adenosine triphosphate（ATP） and guanosine triphosphate（GTP）. cGAMP， as a second messenger， activates the stimulator of interferon gene（STING protein）， promoting the release of type I interferons and thus initiating a series of immune responses. The cGAS-STING pathway can regulate tumor metastasis and growth， participate in anti-tumor innate immune responses， and exploring the mechanism of action of the cGAS-STING pathway is of great significance in tumor immunotherapy. This review introduces the mechanism of action of the cGAS-STING pathway and summarizes various strategies currently used to activate the cGAS-STING pathway in anti-tumor immunotherapy. Table and Figures | Reference | Related Articles | Metrics

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Recent Advances in Carbon Dots with Near-infrared Absorption/Emission LIU Yupeng, YANG Junxiang, HAO Yiming, QU Songnan Chem. J. Chinese Universities    2025, 46 (6): 20240070-.   DOI: 10.7503/cjcu20240070 Abstract （828）   HTML （19）    PDF（pc） （30102KB）（247）       Knowledge map    Save Carbon dots（CDs） are an emerging class of zero-dimensional carbon nano-optical materials that are as promising candidates for various applications. Compared with visible light， near-infrared light has deeper tissue penetration and lower scattering， giving it obvious advantages in fields such as biological imaging. Through the exploration of scientific researchers， the optical band gap of CDs has been continuously regulated and red-shifted from the initial blue-violet light to longer wavelengths. In recent years， CDs with near-infrared absorption/emission have been gradually reported. Based on a series of works by our research group on the near-infrared carbon dots， this review summarizes and reviews the latest progress in preparation strategies and applications of near-infrared carbon dots， and prospectively outlines the future development directions. Table and Figures | Reference | Related Articles | Metrics

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Internal Standard Method-based Surface-enhanced Raman Spectroscopy for Quantitative Analysis BI Yingna, LIU Dingbin Chem. J. Chinese Universities    2025, 46 (2): 20240457-.   DOI: 10.7503/cjcu20240457 Abstract （818）   HTML （38）    PDF（pc） （13761KB）（537）       Knowledge map    Save Surface-enhanced Raman spectroscopy（SERS） is a spectral detection method that has been widely used in the fields of disease diagnosis， drug screening， and biological analysis， etc. It can not only provide rich chemical fingerprint information but also has the advantages of high sensitivity， resistance to photobleaching， and photodegradation. However， due to the poor uniformity of its enhancement matrix structure and the uncertainty of the number of chemical molecules adsorbed， the reproducibility of SERS detection results is poor， which makes it face many challenges in quantitative analysis. The deployment of internal standards could eliminate the external interference factors， thus achieving accurate quantitative analysis. We set out this review with a description of the mechanism of internal-standard methods， followed by introducing their main types. Thereafter， we introduced explanations of the applications of internal-standard probes in environmental analysis， food and drug analysis， and biological analysis. We conclude with an outlook of challenges and future development directions of internal-standard SERS. Table and Figures | Reference | Related Articles | Metrics

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Research Progress in Supramolecular Drug Delivery Nanosystems Based on Polyphenols YAN Ziliang, LI Bei, DAI Yunlu Chem. J. Chinese Universities    2025, 46 (1): 20240260-.   DOI: 10.7503/cjcu20240260 Abstract （776）   HTML （24）    PDF（pc） （32893KB）（179）       Knowledge map    Save Supramolecular drug delivery nanoplatforms have attracted much attention due to their diverse functions， controllable drug-releasing property， and unsophisticated techniques for preparation. Polyphenols with phenolic hydroxyl structure have been reported to easily have non-covalent interactions with different drugs， next self- assembling to be supramolecular nanosystems and successfully delivering drugs through desirable administrations. Moreover， polyphenols per se are generally active in defensing tumor， bacteria， oxidative species， inflammation， and protecting cardiac function， which can broaden the biomedical application scope of polyphenol-based delivery systems. In this review， we comprehensively depict the supramolecular interactions involved in the polyphenol-based supramolecular drug delivery systems， and detailedly explain how the interaction force highly affects the drug loading（e.g.， hydrophobic drugs， proteins， and DNA， etc.）. Finally， the controversial issues existing in current polyphenol-based supramolecular nanosystems are summarized and reviewed. This article is expected to shed a new light on the rational designs and fundamental studies of emerging polyphenol-based materials. Table and Figures | Reference | Related Articles | Metrics

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Research Progress in Nanomaterial-induced Cuproptosis in Tumor Cells HE Kuo, DING Binbin, MA Ping’an, LIN Jun Chem. J. Chinese Universities    2025, 46 (1): 20230525-.   DOI: 10.7503/cjcu20230525 Abstract （765）   HTML （21）    PDF（pc） （33885KB）（179）       Knowledge map    Save Nanomaterials are considered as promising cancer treatment materials by selectively inducing programmed cell death（PCD） of tumor cells. Cuproptosis is a newly discovered PCD pattern caused by intracellular copper ion overload， characterized by the aggregation of acylated mitochondrial enzymes and the loss of Fe-S proteins. Various nanomaterials have been developed to induce cuproptosis in tumor cells as a treatment for cancer. Numerous studies have demonstrated that cuproptosis achieves better anti-tumor effects when combined with other tumor therapeutic modalities， showing a great potential. This paper introduces the mechanisms and characteristics of cellular cuproptosis， outlines the strategies and mechanisms of nanomaterial-induced cuproptosis in tumor cells， focuses on classifying and outlining the recent research progress of nanomaterial-induced cuproptosis combination therapy， and looks forward to the future prospects of this emerging therapeutic modality. Table and Figures | Reference | Related Articles | Metrics

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First-principles Study on the Catalysis of OER/ORR by N-doped Graphene with Defects HUANG Zhiyao, LI Li, XU Huaqing, YANG Yifan, WEI Yaoyao, LIU Guokui, XIA Qiying Chem. J. Chinese Universities    2025, 46 (2): 20240430-.   DOI: 10.7503/cjcu20240430 Abstract （721）   HTML （20）    PDF（pc） （2927KB）（504）       Knowledge map    Save Non-metallic doped graphene-based catalysts have good application prospects in catalyzing oxygen evolution reaction（OER） and oxygen reduction reaction（ORR）. Based on the common double vacancy defects of graphene， non-metallic N-doped catalytic material was constructed and all possible active sites were studied. Through DFT calculation， we find that none of the 13 carbon active sites can effectively adsorb H2O， while O2 can be effectively adsorbed. The calculation results show that the optimal catalytic site for ORR is C12， with the overpotential of 0.71 V for catalyzing ORR， followed by the C10 site adjacent to pyridine N and C3 site， with the overpotentials of 0.75 V and 0.78 V， respectively. This study demonstrates that non-metallic N-doped defective graphene materials can be applied to catalyze ORR， providing theoretical support and guidance for non-metallic catalysis in the OER/ORR reactions. Table and Figures | Reference | Supplementary Material | Related Articles | Metrics

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Synthesis of COF-LZU1 in Acetate Buffer and Immobilized Enzyme Study LIU Meng, XU Yi, YANG Fan, ZHOU Quan, REN Jing, REN Ruipeng, LYU Yongkang Chem. J. Chinese Universities    2025, 46 (2): 20240368-.   DOI: 10.7503/cjcu20240368 Abstract （715）   HTML （20）    PDF（pc） （2218KB）（138）       Knowledge map    Save COF-LZU1 was synthesized in acetate buffer at room temperature and used to immobilize laccase and horseradish peroxidase. Firstly， by optimizing the reaction conditions such as reaction concentration， reaction time， pH value of the acetate buffer， reaction temperature， washing solvent and drying method. In acetate buffer， COF-LZU1 was synthesized with high crystallinity at pH=4.5 with stirring at room temperature for 30 min， which has high specific surface area up to 501 m2/g， and higher thermal stability（480 ℃）. Then， under the aforementioned optimal reaction conditions， laccase and horseradish peroxidase were immobilized by in situ embedding with COF-LZU1 as a carrier， and their properties were investigated， which showed that the enzyme activities after immobilization were as high as 84.26% and 73.66%（with respect to the free enzyme activity）， and the relative activities were still maintained at about 80% after cycling for 10 times of use. Through multiple binding sites， COF-LZU1 effectively stabilized the active conformation of the enzyme， which made it less prone to structural deformation and improved the thermal stability， pH stability and reusability of the enzyme， etc. Acetate buffer is a commonly used buffer in biochemical experiments， which was used as both a solvent and a catalyst in the present experiments. Compared with the existing synthetic methods， the method has a better effect on the stability of biomolecules and is expected to provide a new solution for enzyme immobilization. Table and Figures | Reference | Supplementary Material | Related Articles | Metrics

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Preparation of Broad-spectrum UV Protection Carbon Dots for the Application of Sunscreen Absorber CHEN Qidan, CHEN Guanji, YOU Shanmei, ZANG Xinyao, YANG Bai Chem. J. Chinese Universities    2025, 46 (6): 20240313-.   DOI: 10.7503/cjcu20240313 Abstract （689）   HTML （12）    PDF（pc） （6000KB）（192）       Knowledge map    Save Sunscreen absorber， the basic ultraviolet（UV） protection additives that absorb UV rays， is the active ingredient in sunscreen products. However， traditional sunscreen absorbers are known as organic and inorganic chemicals which have problems such as unknown toxicity for human health and environment， instability， poor water solubility， and a narrow range of UV absorption， the study of eco-friendly broad-spectrum sunscreen absorber materials is important for the application of sunscreen products. In recent years， carbon dots have shown good properties in the application of UV absorbers due to their chemistry stability， eco-friendly， excellent UV absorption efficiency. In this study， two kinds of carbon dots（named O-CDs and A-CDs， respectively） were prepared from dopamine hydrochloride and o-phenylenediamine， citric acid and urea independently by simple one-pot hydrothermal synthesis method， purified by column chromatography and then characterized by X-ray photoelectron spectroscopy（XPS）， transmission electron microscopy（TEM）， X-ray diffraction（XRD）， Fourier transform infrared spectroscopy（FTIR）， Ultraviolet-visible spectroscopy（UV-Vis）， and fluorescence spectroscopy. The results showed that a broad-spectrum UV protection material named as B-CDs was developed by mixing O-CDs and A-CDs with the optimized mass ratio of 1∶1.5. In addition， the B-CDs were added as a broad-spectrum UV absorber to polyvinyl alcohol（PVA） solution to prepare the UV protection calligraphy ink， and the sunscreen effect stability of the ink was tested in a certain period（120 h）. The results indicated that the broad-spectrum carbon dots UV absorber is high- efficiency and stable， and carbon dots have the potential to be used as ideal photostable broad-spectrum UV absorber additives for sunscreen products. Table and Figures | Reference | Related Articles | Metrics

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Influence of Polycyclic Aromatic Hydrocarbon Molecular Framework on Single-molecule Conductance WANG Mingzhen, WANG Zhiye, LI Mengxiao, LU Yuhua, WANG Xu, LI Yunchuan Chem. J. Chinese Universities    2025, 46 (2): 20240429-.   DOI: 10.7503/cjcu20240429 Abstract （663）   HTML （18）    PDF（pc） （4103KB）（428）       Knowledge map    Save The charge transport process within molecular junctions is influenced by many factors， including the molecular backbones and anchoring groups. In this paper， to investigate the impact of the molecular backbone on the charge transport properties of molecular junctions， we designed and synthesized three kinds of polycyclic aromatic hydrocarbons（PAHs） with different fused-ring core（benzene， naphthalene and anthracene） as molecular skeleton and thiophene as anchor group. Scanning tunneling microscope break junction（STM-BJ） measurement and density functional theory（DFT） -based calculations were performed to investigate the charge transport process of single PAHs junctions. The STM experimental results of three molecules exhibit two distinct conductivity states， designated as high conductance states（GH） and low conductance states（GL）， which correspond to the two binding configurations of Au-π and Au-S within single molecular junctions for three molecules. In the case of the GL state， the increase of fused-ring core effectively shifts the HOMO level closer to the Au Fermi level， resulting in a conductance trend of GDT-A>GDT-N>GDT-B. In the GH state， the conductance value of three molecular junctions will not change obviously with the increase of π-conjugated area， but the increase in twist angle of PAHs results in an enhancement of steric hindrance， which reduces the probability of Au-π bonding configuration， ultimately leading to a change in the formation ratio of the two molecular configurations of Au-π and Au-S. Table and Figures | Reference | Supplementary Material | Related Articles | Metrics

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Application of Nanozyme-based Micro/nanomotors in Smart Drug Delivery ZHANG Dang, SUN Xiaomin, YANG Haiyue, SONG Bohan, CONG Meng, WANG Yuxin, DING Feng, XU Shanshan, BI Sai, WANG Lei Chem. J. Chinese Universities    2025, 46 (1): 20240468-.   DOI: 10.7503/cjcu20240468 Abstract （659）   HTML （18）    PDF（pc） （17644KB）（548）       Knowledge map    Save To solve the problems of instability， inactivation of natural enzymes and to tackle the limitations of low delivery efficiency， nanozyme-based micro/nanomotors have been designed and prepared. These motors， with the combination of the efficient and stable catalytic ability of nanozyme and the autonomous motion capability of micro/ nanomotors， could achieve active targeted drug delivery at the diseased site and respond to specific signals for intelligent and controllable drug release， therefore exhibiting significant potential in smart drug delivery applications. Following the developing idea of “from motility， to controllability and applicability”， this paper provides a comprehensive review of various types of nanozymes， discusses the motion regulatory strategies of micro/nanomotors， systematically reviews the cutting-edge applications of nanozyme-based micro/nanomotors in precision drug delivery， and summarizes the challenges and future development prospects for this technology in practical application， wishing to provide fundamental guidance for the development of this field. Table and Figures | Reference | Related Articles | Metrics

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Research Progress on Eutectic Gallium-indium and Self-assembled Monolayer-based Functional Molecular Junctions CHEN Xiaoping, HUANG Shi, GUO Qianqian, LIU Ning, NI Jiancong, YANG Weiqiang, LIN Zhenyu Chem. J. Chinese Universities    2025, 46 (2): 20240451-.   DOI: 10.7503/cjcu20240451 Abstract （648）   HTML （18）    PDF（pc） （14619KB）（463）       Knowledge map    Save Functional molecular electronics based on eutectic gallium⁃indium as top electrode and self-assembled monolayer（SAM） as active layer is one of the research hotspots in recent years. Domestically， the study on EGaIn-based functional molecular junctions（MJ） is still in the beginning state. This review introduces the advantages of EGaIn as top electrode and the fabrication of SAM-MJ in detail， and shows recent workers on rectifiers， memory， opto-electrical switches， thermoelectrics， and solid-state impedance and so on. We analyze the challenges of EGaIn-based molecular junctions and propose the future development directions. Table and Figures | Reference | Related Articles | Metrics

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Ultrasound-aided Cellular Uptake and Endosomal Escape of Nanoparticles via the Membrane Surface Redox Reaction LI Yao, ZHAI Wanying, WANG Zheng, Petrov Alexey M., ZHANG Baoxin, ZHAO Yanjun Chem. J. Chinese Universities    2025, 46 (1): 20240265-.   DOI: 10.7503/cjcu20240265 Abstract （635）   HTML （9）    PDF（pc） （5993KB）（109）       Knowledge map    Save Cellular uptake and endosomal escape are two critical biological barriers to nanoscale drug delivery. The exofacial thiols at cell surface have been previously reported to simultaneously overcome these two barriers via the thiol-disulfide/diselenide exchange reaction. However， the power of such approach for nanomedicine delivery enhancement was limited. To address the above issue， we employed the mechanical force（ultrasound） that could significantly enhance the kinetics of thiol-disulfide/diselenide exchange reactions， and then the delivery efficiency. The discovery in the current work opens new avenues of tailored nanomedicine design to circumvent the delivery hurdles. Table and Figures | Reference | Supplementary Material | Related Articles | Metrics

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Theoretical Study of B， N Co-doped Fullerene C70 as Non-metal Electrocatalysts for Oxygen Reduction and Evolution YANG Siwei, HUANG Xuri Chem. J. Chinese Universities    2025, 46 (4): 20240490-.   DOI: 10.7503/cjcu20240490 Abstract （635）   HTML （35）    PDF（pc） （3465KB）（140）       Knowledge map    Save The oxygen reduction reaction（ORR） and oxygen evolution reaction（OER） properties for B， N co-doped fullerene C70［C68B（n）N（m）， n， m=1—5， representing the C atom sites substituted by B and N， respectively］ were investigated utilizing density functional theory. It is found that C68B（n）N（m） are thermodynamically stable， and their ΔG*OH has a good linear relationship with ΔG*OOH and ΔG*O. Wherein， the ORR overpotential for C68B（4）N（2） and C68B（5）N（2） catalysts are both 0.45 V， which is equivalent to that of commercial Pt catalyst. The OER overpotential of C68B（4）N（1） is the lowest， 0.38 V， which is better than that of the traditional RuO2 catalyst（0.42 V）. C68B（1）N（3） also shows the OER activity equivalent to that of RuO2. The overpotential of ORR and OER can be significantly reduced and the catalytic performance of C70 can be improved by accurately adjusting the sites of B and N co-doping. According to the activity trend plots， the best ORR and OER activities for C68B（n）N（m） appear at ΔG*O-ΔG*OH=0.92 eV and ΔG*O-ΔG*OH=1.42 eV， respectively. This work provides some clues for the design and discovery of novel non-metallic carbon-based electrocatalysts. Table and Figures | Reference | Related Articles | Metrics

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Machine Learning Model for Predicting the Glass Transition Temperature of Polyimides Based on Molecular Fingerprints and Quantum Chemical Descriptors ZHAN Senhua, SHI Tongfei Chem. J. Chinese Universities    2025, 46 (4): 20240556-.   DOI: 10.7503/cjcu20240556 Abstract （635）   HTML （22）    PDF（pc） （2175KB）（126）       Knowledge map    Save Combining machine learning and quantum chemistry methods to construct predictive models can facilitate the design and screening of polyimide material structures. In this study， Molecular ACCess System（MACCS） fingerprints and nine density functional theory（DFT） quantum chemical descriptors were obtained from polyimide repeating units to construct three types of predictive models： MACCS， DFT and their integrated models. Twelve machine learning models were developed using four algorithms——random forest（RF）， support vector regression （SVR）， extreme gradient boosting（XGB） and gradient boosting regression（GBR）——to predict the glass transition temperature of polyimides and extract key feature information. The results showed that the optimal predictive model for the glass transition temperature is the integrated XGBoost model， with coefficient of determination（R²） values of 0.956 and 0.811 for the training and test sets， respectively. The root mean square error（RMSE） and mean absolute error（MAE） for the test set are 25.41 and 20.20， respectively. Furthermore， the integrated MACCS fingerprint and DFT models performed better than the individual models. The established integrated model framework provides new insights for the structural design of polyimide materials and other polymer materials. Table and Figures | Reference | Related Articles | Metrics

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Ring-opening Preparation of Poly（disulfide）s for Drug Delivery SUN Yujie, NIU Zhentian, TONG Haoxuan, HU Yue, YU Bingran, XU Fujian Chem. J. Chinese Universities    2025, 46 (1): 20240116-.   DOI: 10.7503/cjcu20240116 Abstract （634）   HTML （22）    PDF（pc） （16585KB）（195）       Knowledge map    Save The dynamic exchange and recombination of disulfide bonds make it easy to polymerization to obtain poly（disulfide）s， among which ring-opening polymerization（ROP） is a common preparation method. The environmental sensitivity of poly（disulfide）s makes it widely used in the field of drug delivery. In this paper， the ROP strategies of disulfide are reviewed， which are mainly divided into ring-opening self-polymerization and thiol-induced disulfide exchange polymerization. Then， the latest research progress of poly（disulfide）s in drug delivery is also discussed， including nucleic acid delivery， protein delivery and small molecule drug delivery. Last， the ROP stategies and application in drug delivery of poly（disulfide）s are prospected. Table and Figures | Reference | Related Articles | Metrics

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Discovery of CDK2 Inhibitors Based on Machine Learning and Molecular Dynamics Simulations TAN Yingjia, CHEN Liang, LIU Yulin, NA Risong, ZHAO Xi Chem. J. Chinese Universities    2025, 46 (3): 20240442-.   DOI: 10.7503/cjcu20240442 Abstract （627）   HTML （12）    PDF（pc） （7091KB）（390）       Knowledge map    Save Four potential cyclin-dependent kinase 2（CDK2） inhibitors were discovered through machine learning and molecular dynamics simulation methods. First， a classification model for CDK2 inhibitors was established using existing large-scale activity databases and machine learning algorithms. The extreme gradient boosting（XGBoost） model with extended-connectivity fingerprints（ECFP6） was used to screen the Enamine database， identifying 1152 novel compounds. These potential compounds were then ranked based on their affinity for CDK2 using molecular docking and scoring functions. The compounds were clustered into four categories using fingerprint clustering methods， and one compound with a high docking score was selected from each category. Subsequently， the four selected compounds underwent drug-likeness analysis and molecular dynamics simulations. The four potential CDK2 inhibitors（Z1766368563， Z363564868， Z1891240670 and Z2701273053） demonstrated good drug-likeness properties and high binding free energy in molecular dynamics simulation results. The findings suggest that these four compounds can serve as lead compounds for subsequent modification and optimization as CDK2 inhibitors. Table and Figures | Reference | Supplementary Material | Related Articles | Metrics

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High-throughput Calculations of Host-guest Interactions Between Organic Structure-directing Agents and Zeolite Structures with Different Elemental Compositions LI Lin, WANG Chen, WANG Jiaze, LI Li Chem. J. Chinese Universities    2025, 46 (4): 20240497-.   DOI: 10.7503/cjcu20240497 Abstract （617）   HTML （38）    PDF（pc） （1553KB）（327）       Knowledge map    Save Zeolites are inorganic microporous crystalline materials with regulated channel structures， which are widely used in industrial adsorption separation and catalytic processes. This work selected 14 topologies that can be synthesized in the form of pure silica， aluminosilicate， and aluminophosphate from over 260 known zeolite topologies， and explored the structure-directing effects of different organic structure-directing agents（OSDAs） for zeolite frameworks with different compositions via high-throughput computational methods. Results show that the OSDAs significantly affects the elemental composition of zeolites， with certain OSDAs tending to direct the formation of pure silica or aluminosilicate structures， while others preferentially direct towards pure aluminophosphate structures. These findings not only deepen the understanding of the synthetic mechanism of zeolites， but also provide a theoretical basis for the design and synthesis of zeolites with specific elemental compositions. Table and Figures | Reference | Supplementary Material | Related Articles | Metrics

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First-principles Study of Doping and Point Defects Modulating the Photodissociative Water Properties of MoS2/ZnO Heterojunction WEN Junqing, WANG Jiahui, ZHANG Jianmin Chem. J. Chinese Universities    2025, 46 (2): 20240380-.   DOI: 10.7503/cjcu20240380 Abstract （612）   HTML （15）    PDF（pc） （17502KB）（129）       Knowledge map    Save The electronic structures， optical properties and photocatalytic performance of MoS2/ZnO heterojunction doping with C and Pd elements and point defects were studied using first principles calculations. The stable sites of C and Pd atom doping MoS2/ZnO heterojunction is S2 and Zn site， and the stable defect point is Zn defect. The analysis of electronic structures shows that band edge position of the intrinsic MoS2/ZnO presents a type II band alignments with a direct band gap of 0.66 eV. Doping and defects can effectively regulate the band gap of MoS2/ZnO. Pd@Zn system exhibits magnetic semiconductor， VMo and VZn systems exhibit magnetic metallic properties. Doping and defects increase the light absorption coefficient of MoS2/ZnO heterojunction in the visible light range（500—760 nm）. Intrinsically， there is a built-in electric field from ZnO layer to MoS2 layer at the interface in the doping and defective MoS2/ZnO， which promotes charge transfer from ZnO layer to MoS2 layer. The charge transfer amount of Pd@Zn， C@S2&Pd@Zn increases. The intrinsic MoS2/ZnO， C@S2， Pd@Zn， VS1， VS2 and VO systems form direct Z-type heterojunctions， which promote the effective separation of photo generated electron hole pairs. The band edge potential of MoS2/ZnO， C@S2， Pd@Zn， VS1， VS2 and VO crosses the oxidation-reduction potential at pH=0 and 7， indicating that these heterojunctions can undergo oxidation-reduction reactions under strong acid solution and neutral solution conditions， and the carriers have strong oxidation-reduction ability. Table and Figures | Reference | Related Articles | Metrics

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Component-tunable PdRh Bimetallic Nanozyme for Ultra-sensitive Colorimetric Detection of Nitrite TANG Yuxi, YANG Qi, ZHI Xinpeng, CHEN Mengyuan, LIU Siyuan, LI Jiachang, LIU Ziyang, JIA Huimin, TONG Yuping, HE Weiwei Chem. J. Chinese Universities    2025, 46 (1): 20240341-.   DOI: 10.7503/cjcu20240341 Abstract （605）   HTML （6）    PDF（pc） （8343KB）（790）       Knowledge map    Save A series of bimetallic nanozymes（Pd3Rh， PdRh， PdRh3） was prepared using one-pot hydrothermal method by adjusting the ratio of palladium（Pd） to rhodium（Rh）. The peroxidase-like（POD-like） and oxidase-like（OXD-like） activities of nanozymes were tested. The results showed that the catalytic activity of bimetallic nanozymes was significantly enhanced compared to that of single metallic nanozymes（Pd， Rh）. The POD-like and OXD-like activities exhibited obvious component dependence， and PdRh3 and PdRh nanozyme showed the strongest POD-like and OXD-like activity， respectively. The analysis of enzymatic kinetics showed that the Michaelis-Menten constant （Km） of PdRh3 nanozyme with 3，3'，5，5'-tetramethylbenzidine（TMB） and H2O2 as substrates are 15.65 and 381.99 μmol/L， respectively. The corresponding maximum velocity（vmax） reach 8.40×10-8 and 11.01×10-8 mol/（L·s）. In addition， the POD-like activity of PdRh3 nanozyme was pH-dependent， and the optimized activity was obtained at pH=5. A colorimetric sensing system was developed based on PdRh3 nanozyme， which realized the rapid quantitative detection of nitrite concentration in solution according to the fitting relationship between the absorbance ratio（A445 nm/A652 nm） and the concentration of nitrite ion（NO2-）. The limit of detection（LOD） in pH=5 buffer and pure water are 0.467 and 30.523 μmol/L， respectively， and the system has a good specificity under the interference of various salt ions， demonstrating great application potential in biosensing. Table and Figures | Reference | Related Articles | Metrics

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Research Progress of Carbon-based Moisture Power Generation Devices LI Qijun, ZHAO Hongjia, LIU Longtao, LU Chunyi, TAN Jing Chem. J. Chinese Universities    2025, 46 (6): 20240413-.   DOI: 10.7503/cjcu20240413 Abstract （571）   HTML （10）    PDF（pc） （31544KB）（150）       Knowledge map    Save Moisture-enabled electricity generation（MEG）， an emerging energy-harvesting technology， has attracted significant attention in recent years. Owing to the ubiquitous presence of water vapor and the pollution-free nature of the power generation process， MEG technology demonstrates strong adaptability， that is， it is not limited by natural conditions such as season， region and environment. This paper presents a comprehensive review of the evolution of MEG technology. It discusses the interaction mechanism between moisture and power generation materials， primarily focusing on ion gradient diffusion and streaming potential. It also provides a detailed analysis of the types， characteristics， advantages and disadvantages of new carbon-based hygroscopic layer materials. Furthermore， it describes the development of moisture power generation technology in the latest application fields. Table and Figures | Reference | Related Articles | Metrics