Abstract: Pharmaceutical cocrystal is a new type of pharmaceutical crystalline state. It is attractive to pharmaceutical scientists because it can provide a number of crystalline states for a given active pharmaceutical ingredient (API), in which the physical and chemical properties of the API can be adjusted by pharmaceutical cocrystal. In this review, we address pharmaceutical cocrystals from the perspective of supramolecular chemistry, and present a series of structures of pharmaceutical cocrystals constructed through hydrogen bonding supramolecular synthons, in which the physical and chemical properties (solubility, bioavailability, melting point etc.) of APIs can be changed by pharmaceutical cocrystal.

Key words: Supramolecular chemistry; , Pharmaceutical cocrystal; , Hydrogen bond; , Supramolecular synthon