Abstract: Triazole ring contains three nitrogen atoms, is a quite important five-member heterocycle and possesses aromaticity and rich electrons. This unique structure endows triazole moiety to readily accept protons and coordinate with various metal ions. Therefore triazole compounds easily form supramolecular aggregates via non-covalent interaction such as coordination bonds, hydrogen bonds, ion-dipole, cation-?, ?-? stacking, hydrophobic effect, van der Waals force and so on. These triazole derivatives exhibit various special properties and biological activities, and display a wide range of potential application as artificial ion receptors, materials and medicinal agents. In recent years, the related researches of triazole-based supramolecular chemistry and medicinal drugs have been becoming an extremely active, quite rapidly developing and attracting highlight area. Combining with authors’ researches and referring other works from literatures in recent 5 years, this work for the first time systematically reviewed the recent advance of the whole range of triazole-based compounds as cation and anion receptors and triazole supermolecules as luminescent and magnetic materials as well as medicinal drugs majoring in antibacterial, antifungal, anticancer agents. Hopefully, this review would be helpful for the further researches and development of the triazole-based supramolecular chemistry and medicinal drugs.

Key words: Triazole, Supermolecule, Complex, Luminescent material, Anticancer