Synthesis of Cationic Lipids Containing Bis\|cyclen Units and Interaction with DNA

Chem. J. Chinese Universities ›› 2011, Vol. 32 ›› Issue (9): 2157.

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Synthesis of Cationic Lipids Containing Bis\|cyclen Units and Interaction with DNA

CHEN Hong^1,2, LIAO Yi-Le¹, HUANG Qing-Dong¹, WU Jiang^1*, YU Xiao-Qi^1*

1. Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China; 
2. Department of Basic Sciences, Rongchang Campus, Southwest China University, Chongqing 402460, China

Received:2011-01-24 Revised:2011-05-27 Online:2011-09-10 Published:2011-08-11
Contact: YU Xiao-Qi;WU Jiang E-mail:xqyu@tfol.com;wujiang@scu.edu.cn
Supported by:
国家自然科学基金(批准号: 20972104, 20725206, 20732004)资助.

Abstract

Abstract: The clinical success of gene therapy requires a safe and effective gene delivery system. Cationic lipids have particularly excellent potential for gene delivery applications because of their lesser immunogenic nature, robust manufacture ability to deliver large pieces of DNA, and ease of handling and preparation techniques. In this study, two bis-cyclen-based cationic lipids were designed and synthesized, and their structures were characterized by 1H NMR and HRMS. Liposomes were easily prepared by mixing cationic lipids with DOPE. Agarose gel electrophoresis demonstrated that the liposomes could completely condense DNA at N/P ratio of 6. The results suggested that the synthesized cationic lipids might be of potential as non-viral gene carrier.

Key words: Cyclen, Synthesis, Cationic lipid, Gene vector

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CHEN Hong, LIAO Yi-Le, HUANG Qing-Dong, WU Jiang*, YU Xiao-Qi*. Synthesis of Cationic Lipids Containing Bis\|cyclen Units and Interaction with DNA[J]. Chem. J. Chinese Universities, 2011, 32(9): 2157.

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Synthesis of Cationic Lipids Containing Bis\|cyclen Units and Interaction with DNA

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