Progress of Cucurbit[n]urils in Drug Delivery System

Chem. J. Chinese Universities ›› 2011, Vol. 32 ›› Issue (9): 2022.

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Progress of Cucurbit[n]urils in Drug Delivery System

HUANG Ying^1,2, TAO Zhu^1*, XUE Sai-Feng¹, ZHU Qian-Jiang¹

1. Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province,
2. Engineering and Research Center for Southwest Bio\|pharmaceutical Resources, Ministry of Education, Guizhou University, Guiyang 550025, China

Received:2011-03-29 Revised:2011-05-09 Online:2011-09-10 Published:2011-08-11
Contact: TAO Zhu E-mail:gzutao@263.net
Supported by:
国家自然科学基金(批准号: 20972034)、贵州省省长资金(批准号: 黔省专合字(2009)103号)、贵州省科技厅自然科学基金(批准号: 黔科合J字[2009]2288号)、贵州省教育厅自然科学基金(批准号: 黔教科2010013)和贵州大学引进人才项目[批准号: 贵大人基合字(2009)023号]资助.

Abstract

Abstract: As a type of novel synthetic acceptor, cucurbit[n]urils(Q[n]s) which has the unique structure with hydrophobic central cavity and hydrophilic carbonyl group portals, can selectively bind different guest molecules to form self-assembly host-guest complexes, capsules and supramolecular entities. Thus, cucurbit[n]uril could be used in many different fields, such as environment, pharmacology, separation and material. Combining with our researches and referring other works from literatures, this paper reviewed the recent advance of cucurbiturils in the drug carriers and drug delivery, and the prospect of the cucurbituril in pharmacology were also presented.

Key words: Cucurbit[n]uril, Drug carrier, Drug delivery

CLC Number:

06-1

TrendMD:

HUANG Ying, TAO Zhu, XUE Sai-Feng, ZHU Qian-Jiang. Progress of Cucurbit[n]urils in Drug Delivery System[J]. Chem. J. Chinese Universities, 2011, 32(9): 2022.

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Progress of Cucurbit[n]urils in Drug Delivery System

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