Synthesis of New [12]aneN3 Compounds and Their Catalytic Cleavage of Phosphodiester

Chem. J. Chinese Universities ›› 2011, Vol. 32 ›› Issue (9): 2128.

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Synthesis of New [12]aneN3 Compounds and Their Catalytic Cleavage of Phosphodiester

GUO Zhi-Fo, YAN Hao, LI Zhi-Fen, LU Zhong-Lin*

College of Chemistry, Beijing Normal University, Beijing 100875, China

Received:2011-03-28 Revised:2011-06-22 Online:2011-09-10 Published:2011-08-11
Contact: LU Zhong-Lin E-mail:luzl@bnu.edu.cn
Supported by:
国家自然科学基金(批准号: 20972019)和高校博士点新教师基金(批准号: 273911)资助.

Abstract

Abstract: Design, synthesis, and catalytic performance of artificial nucleases is full of challenging and has received intensive study in chemistry. In this work, we report on the synthesis of two new methyl 3,5-dimethylbenzolate derived [12]aneN3 compounds 4a and 4b through high efficient click reactions and their characterization with element analysis, NMR, IR and high resolution MS. The corresponding zinc(II) complexes can greatly promote the cleavage of RNA model phosphodiester 2-hydroxypropyl-4-nitrophenylphosphate (HPNPP) in methanol with an acceleration of 107-fold relative to the background reaction.

Key words: Artificial nuclease, Macrocyclic polyamine, Phosphodiester, Click reaction, Zinc(Ⅱ) complex

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GUO Zhi-Fo, YAN Hao, LI Zhi-Fen, LU Zhong-Lin*. Synthesis of New [12]aneN3 Compounds and Their Catalytic Cleavage of Phosphodiester[J]. Chem. J. Chinese Universities, 2011, 32(9): 2128.

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Synthesis of New [12]aneN3 Compounds and Their Catalytic Cleavage of Phosphodiester

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