高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (2): 305.

• 论文 • 上一篇    下一篇

Nα-磷酰化二肽甲酯的氧化和氧化中电子转移的研究

储高升1, 姚思德2, 陈家富1, 张志成1, 张曼雏1   

  1. 1. 中国科学技术大学应用化学系, 合肥, 230026;
    2. 中国科学院辐射化学开放研究实验室, 上海, 201800
  • 收稿日期:1996-09-16 出版日期:1998-02-24 发布日期:1998-02-24
  • 通讯作者: 储高升,联系人:男,34岁,博士,讲师.
  • 作者简介:储高升,男,34岁,博士,讲师.
  • 基金资助:

    国家自然科学基金资助课题.

Study on Oxidation and Electron Transfer in Phosphoryldipeptide Methyl Ester

CHU Gao-Sheng1, YAO Si-De2, CHEN Jia-Fu1, ZHANG Zhi-Cheng1, ZHANG Man-Wei1   

  1. 1. Dept. of Appl. Chem., Univ. of Sci. and Tech. of China, Hefei, 230026;
    2. Lab of Radiation Chem., Shanghai Inst. of Nuclear Research, The Chinese Academy of Sciences, Shanghai, 201800
  • Received:1996-09-16 Online:1998-02-24 Published:1998-02-24

摘要: 用纳秒级脉冲辐解动态吸收光谱法研究了Br2自由基引发N-(N-二异丙氧基磷酰化甲硫氨酰)色氨酸甲酯的氧化和电子转移过程,结果表明:Br2自由基同步氧化Nα-磷酰化二肽中的甲硫氨酸和色氨酸部位,并发生由色氨酸向含硫三电子键自由基的分子内电子转移过程,求算了有关动力学参数,推导了氧化和电子转移机理.

关键词: 脉冲辐解, N&alpha, -磷酰化二肽, 氧化, 电子转移

Abstract: The Br2 induced oxidation and electron transfer in N-(N-phosphorylmethionyl) tryptoyl methyl ester (NDM—TrpOMe) in aqueous solution were investigated using pulse radiolysis technique. The results indicated that the N-phosphoryl methioyl and tryptoyl group were oxidized by Br2 radicals simultaneously, and intramolecular electron transfer from tryptophan to the three-electron-bonded intermediate containing sulfur occured. Some kinetic parameters were determined and the reactive mechanism was deduced.

Key words: Pulse radiolysis, Nα-Phosphoryldipeptide, Oxidation, Electron transfer

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