Selenazole Carboxamide Src Kinase Inhibitor against Aβ-Induced Toxicity in Alzheimer’s Disease

doi:10.7503/cjcu20260241

Chem. J. Chinese Universities

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Selenazole Carboxamide Src Kinase Inhibitor against Aβ-Induced Toxicity in Alzheimer’s Disease

Hao Wu¹, Lei Wang¹, Yang Liu¹, Xinwei Zhang¹, Xinliang Pan¹, Mingjie Zhang¹, Fengyu Jiang¹, Junhai Xiao², Feng Lin¹

1. School of Life Sciences, Jilin University
2. Academy of Military Medical Sciences, Academy of Military Sciences

Received:2026-06-21 Revised:2026-07-16 Online First:2026-07-27 Published:2026-07-27
Contact: Feng Lin E-mail:linfeng@jlu.edu.cn
Supported by:
Supported by the Natural Science Foundation of Science and Technology Agency of Jilin Province of China (No. 20220101268JC)

Abstract

Abstract: The study aimed to investigate the effects of Src tyrosine protein kinase inhibitor (SAFA320) on transgenic Caenorhabditis elegans CL4176, as well as its possible mechanism. In the study, C. elegans CL4176 adminstrated with SAFA320 could reduce the deposition of Aβ oligomer to alleviate nematode paralysis, and decrease ROS production. Results of tissue Src kinase activity spectrophotometry analysis showed that SAFA320 could reduce the activities of Src in C. elegans. Meanwhile, the genes expression of skn-1 and its downstream target gene gst-4 were significantly increased, suggesting that compound inhibited Aβ toxicity may involve in SKN-1 signaling pathway in CL4176. In conclusion，SAFA320 is effective in alleviating Aβ toxicity and improving cognitive functions in C. elegans CL4176, and it is a potent candidate agent against AD.

Key words:

Alzheimer’s disease, , Src inhibitor (SAFA320), , amyloid beta, , skn-1, , Caenorhabditis elegans

CLC Number:

O626.2

TrendMD:

Hao Wu, Lei Wang, Yang Liu, Xinwei Zhang, Xinliang Pan, Mingjie Zhang, Fengyu Jiang, Junhai Xiao, Feng Lin. Selenazole Carboxamide Src Kinase Inhibitor against Aβ-Induced Toxicity in Alzheimer’s Disease[J]. Chem. J. Chinese Universities, doi: 10.7503/cjcu20260241.

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Selenazole Carboxamide Src Kinase Inhibitor against Aβ-Induced Toxicity in Alzheimer’s Disease

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