Chem. J. Chinese Universities
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Rui Luo1, Xinwei Zhang1, Yang Liu1, Lei Wang 1, Xiaojun Wu1, Junhai Xiao2, Feng Lin1
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Supported by the Natural Science Foundation of Science and Technology Agency of Jilin Province of China (No. 20220101268JC)
Abstract: This study aimed to investigate the neuroprotective effects of the Src tyrosine kinase inhibitor Y-11 in transgenic APP/PS1 mice. Mice administrated with Y-11 could significantly improve cognitive deficits in Alzheimer’s disease (AD) and reduce the expressions of AD-related pathological proteins in the brain. Meanwhile, Y-11also attenuated neuroinflammation and synaptic dysfunction by inhibiting glial cell activation, and restored synaptic protein levels. In summary, the results suggested that Y-11 had neuroprotective effects on AD mice, provided a theoretical basis on the potential therapeutic application of Src kinase inhibitors in Alzheimer’s disease.
Key words: Src kinase inhibitors, Alzheimer’s disease, 1,3-selenazole-5-formamide derivates
Src kinase inhibitors,
CLC Number:
O626.2
TrendMD:
Rui Luo, Xinwei Zhang, Yang Liu, Lei Wang , Xiaojun Wu, Junhai Xiao, Feng Lin. Neuroprotective Effects of Novel Src Kinase Inhibitor on APP/PS1 Mice[J]. Chem. J. Chinese Universities, doi: 10.7503/cjcu20260242.
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URL: http://www.cjcu.jlu.edu.cn/EN/10.7503/cjcu20260242
