B（C6F5）3-Catalyzed Synthesis of 3，3′-Bisindolylmethane Derivatives

doi:10.7503/cjcu20200509

Chem. J. Chinese Universities ›› 2020, Vol. 41 ›› Issue (10): 2225.doi: 10.7503/cjcu20200509

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B（C₆F₅）₃-Catalyzed Synthesis of 3，3′-Bisindolylmethane Derivatives

MA Jinyu¹, LIU Shuanglei¹, ZHANG Zhenguo¹, JIN Junyang², JIA Zhenhua¹()

^1.Institute of Advanced Synthesis，School of Chemistry and Molecular Engineering，Nanjing Tech University，Nanjing 211816，China
^2.Key Laboratory for Light?weight Materials，Nanjing Tech University，Nanjing 211816，China

Received:2020-07-31 Online:2020-10-10 Published:2020-10-08
Contact: JIA Zhenhua E-mail:iaszhjia@njtech.edu.cn
Supported by:
This paper is supported by the Start-up Grant of Nanjing Technogy University（No.38037037） and the SICAM Fellowship from Jiangsu National Synergetic Innovation Center for Advanced Materials.

Abstract

Abstract:

Herein， we report a simple and direct protocol for preparing the 3，3′-bisindolylmethane derivatives with indoles and aryl aldehydes as the substrates via a B（C₆F₅）₃-catalyzed process of dehydration. The model reaction was detected with full conversion in 15 min. The scope of the substrates is broad and kinds of functional groups are tolerant as well. In this work， the strategy of efficient synthesis of 3，3′-bisindolylme-thane derivatives was developed under mild and transition-metal-free conditions with water as the sole by-pro-duct， which conduced to achieve the quick synthesis of the target products.

Key words: Boron reagent, 3, 3′-Bisindolylmethane derivative, Dehydration

CLC Number:

O626.2

TrendMD:

MA Jinyu, LIU Shuanglei, ZHANG Zhenguo, JIN Junyang, JIA Zhenhua. B（C₆F₅）₃-Catalyzed Synthesis of 3，3′-Bisindolylmethane Derivatives[J]. Chem. J. Chinese Universities, 2020, 41(10): 2225.

Figures/Tables 1

References 17

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B（C₆F₅）₃-Catalyzed Synthesis of 3，3′-Bisindolylmethane Derivatives

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