Chem. J. Chinese Universities ›› 2020, Vol. 41 ›› Issue (10): 2264.doi: 10.7503/cjcu20200246

• Article • Previous Articles     Next Articles

Synthesis of Chiral Phenylbenzothiazole Methanol via Transfer Hydrogenation Catalyzed by Ruthenium Complexes

CHEN Danyi, ZHANG Fumei, HE Dan, ZHANG Zimei, ZHONG Fen, WEN Simiaomiao, LIU Qixing(), ZHOU Haifeng()   

  1. Hubei Key Laboratory of Natural Products Research & Development,College of Biological & Pharmaceutical Sciences,China Three Gorges University,Yichang 443002,China
  • Received:2020-05-03 Online:2020-10-10 Published:2020-06-12
  • Contact: LIU Qixing E-mail:qixingliu86@163.com;zhouhf@ctgu.edu.cn
  • Supported by:
    Supported by Natural Science Foundation of Hubei Province of China(2018CFB241)

Abstract:

A series of chiral phenylbenzothiazole methanol was obtained with up to 99% e.e. value via transfer hydrogenation from phenylbenzothiazolone, with readily available chiral diamine-derived ruthenium complex as a catalyst and sodium formate as a hydrogen source in a mixture of i-PrOH/H2O(volume ratio 1:1) under ambient conditions. In addition, the reduction of other aryl N-heteroaryl ketones was also attempted. This method has the advantages of mild rection conditions, readily available and inexpensive catalysts, simple operation.

Key words: Asymmetric transfer hydrogenation, Chiral diamine ruthenium complex, Phenylbenzothiazole methanol

CLC Number: 

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