Chem. J. Chinese Universities ›› 2020, Vol. 41 ›› Issue (5): 892.doi: 10.7503/cjcu20190673

• Review • Previous Articles     Next Articles

Artificial Regulation of Receptor Clustering and Function on Cell Surface

LI Jingying1,2,CHEN Chen1,2,LI Juan1,*(),YANG Huanghao1   

  1. 1. College of Chemistry, Key Laboratory for Analytical Science of Food Safety and Biology, Ministry of Education
    2. College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, China
  • Received:2019-12-16 Online:2020-05-10 Published:2020-03-19
  • Contact: Juan LI E-mail:lijuan@fzu.edu.cn
  • Supported by:
    † Supported by the National Natural Science Foundation of China(21974022);† Supported by the National Natural Science Foundation of China(91959102);† Supported by the National Natural Science Foundation of China(21635002)

Abstract:

In this review, various strategies for artificial regulation of receptor clustering on cell surface are introduced, which are realized either by physical-stimulations or biological macromolecules. The former one is induced by stimuli-responsive nanomaterials under physical stimulation, such as light, magnetic field, and heat. And the later one is achieved by utilizing the self-assembly of biomolecules including protein, peptide or nucleic acids, thus inducing artificial regulation of their targeting receptor. We aim to systematically introduce advances in this area and provide insights into the existing challenges and future perspectives.

Key words: Receptor clustering, Artificial regulation, Function, Cell surface

CLC Number: 

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