Chem. J. Chinese Universities ›› 2022, Vol. 43 ›› Issue (6): 20220010.doi: 10.7503/cjcu20220010

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Application of DNA Silver Nanoclusters in the Fluorescence Biosensors based on Functional Nucleic Acids

WANG Junyang, LIU Zheng, ZHANG Qian, SUN Chunyan(), LI Hongxia()   

  1. College of Food Science and Engineering,Jilin University,Changchun 130062,China
  • Received:2022-01-06 Online:2022-06-10 Published:2022-02-08
  • Contact: SUN Chunyan E-mail:sunchuny@jlu.edu.cn;hxiali@jlu.edu.cn
  • Supported by:
    the Science and Technology Development Program of Jilin Province, China(20200201218JC);the “Thirteenth Five-Year” Science and Technology Project of Education Department of Jilin Province, China(JJKH20201010KJ);the Outstanding Young Teachers Training Program of Jilin University, China(2132020KJC020)

Abstract:

DNA silver nanoclusters(DNA-AgNCs) are a kind of fluorescent nanoprobes obtained by reducing Ag+ with NaBH4 using DNA as template, because the N atoms on the base heterocyclic are combined with Ag+. Due to the advantages of simple synthesis method, good biocompatibility and adjustable fluorescence emission wavelength, DNA-AgNCs have been widely used in the fields of analysis and detection. In this paper, the application of DNA-AgNCs as label-free fluorescent probes in functional nucleic acids biosensing detection is classified and summarized. In addition, conclusive views on the deficiencies and application potential are put forward, which provide references for future research and application.

Key words: DNA silver nanocluster, Functional nucleic acid, Fluorescence, Biosensor

CLC Number: 

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