高等学校化学学报

高等学校化学学报 ›› 1990, Vol. 11 ›› Issue (10): 1147.

• 研究简报 • 上一篇    下一篇

三乙酸铊氧化3,5-环-24-S-乙基-胆甾-22-烯-6-酮反应的研究

刘兴平1, 李裕林1, 梁晓天2   

  1. 1. 兰州大学有机化学研究所;
    2. 中国医学科学院药物研究所
  • 收稿日期:1989-04-07 出版日期:1990-10-24 发布日期:1990-10-24
  • 通讯作者: 刘兴平, 邮编: 730000

Studies on the Oxidation of 3,5-Cyclo-24-S-Ethyl-Cholcst-22-cne-6-onewith Thallium Triacetate

Liu Xingping1, Li Yulin1, Liang Xiaotian2   

  1. 1. Institute of Organic Chemistry, Lanzhou University, Lanzhou;
    2. Institute of Materia Medial, Chinese Academy of Medical Sciences, Beijing
  • Received:1989-04-07 Online:1990-10-24 Published:1990-10-24

PDF (PC)

被引次数

2

摘要： 油菜甾醇内酯(Brassinolide,1)是一种高效的植物生长促进剂,其活性与侧链C22,C23邻二羟基的构型密切相关,当C22,C23为S,S构型时,其活性仅为1的10%左右[1],在油菜甾醇内酯(1)及其同类物的合成中,C22,C23邻二羟基的引入多采用OsO4氧化法,但所得的主要产物却是非期望的C22S,C23S-二羟基化合物[2～4]。

关键词: 三乙酸铊, 氧化, 油菜甾醇内酯

Abstract: The oxidation of 2 with Thallium triacetate in acetic acid was studied. The cis-glycol(22S, 23S), identical with the major product from Osmium tctraoxide oxidation, was obtained with 62% yield. The mechanism of the oxidation reaction was discussed.

Key words: Thallium triacetate, Oxidation, Brassinolide

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