高等学校化学学报

高等学校化学学报 ›› 2002, Vol. 23 ›› Issue (5): 756.

• 研究论文 • 上一篇    下一篇

新型金属卟啉的合成及其仿酶活性研究

李早英1, 张悦宁1, 朱训进1, 冯清2   

  1. 1. 武汉大学化学与分子科学学院, 武汉 430072;
    2. 华中科技大学同济医学院, 武汉 430030
  • 收稿日期:2001-07-27 出版日期:2002-05-24 发布日期:2002-05-24
  • 通讯作者: 李早英(1949年出生),女,博士,教授,从事金属卟啉的合成及生物活性研究.E-mail:zyliwuc@whu.edu.cn E-mail:zyliwuc@whu.edu.cn
  • 基金资助:

    国家自然科学基金(批准号:29972035);武汉大学2000年自强科学基金资助.

Synthesis of Novel Metalloporphyrins and Their Biological Activityas Mimics of Enzymes

LI Zao-Ying1, ZHANG Yue-Ning1, ZHU Xun-Jin1, FENG Qing2   

  1. 1. College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, China;
    2. College of Tongji Medicine, Huazhong University of Science and Technology, Wuhan 430030, China
  • Received:2001-07-27 Online:2002-05-24 Published:2002-05-24

PDF (PC)

被引次数

57

摘要： 合成并表征了一系列水溶性和非水溶性金属卟啉3a～3e,5a～5f和8a～8f;测试了这些金属卟啉作为超氧化物歧化酶(SOD)和过氧化氢酶(CAT)的模拟物催化歧化O2-和催化分解H2O2等有毒氧自由基的活性及抗脂质过氧化性质.结果表明,含有吡啶溴化盐的水溶性金属卟啉8a～8f的仿酶活性明显大于含有羟基的非水溶性金属卟啉3a～3e和含有酯基的金属卟啉5a～5f.

关键词: 金属卟啉, 合成, 表征, 仿酶活性测试

Abstract: Based on 5,10,15,20-tetrakis(4-hydroxyphenyl)porphyrin(2),a series of non-water soluble and water-soluble metalloporphyrins were synthesized.As mimics of SOD (superoxide dismutase) and CAT(catalase) enzymes, metalloporphyrins 3a-3e, 5a-5f,and 8a-8f, were tested in the assays to dismutase O2-, to decompose H2O2,to clear OH,and to eliminate lipid peroxidation produced in the ho-mogenated livers of mice.Among these metalloporphyrins, 8a-8f, were most effective.Some rules were obtained from the biological activity testing results.

Key words: Metalloporphyrins, Synthesis, Characterizaion, Determination of Biological activity of mimic enzymes

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