高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (8): 1216.

• 论文 • 上一篇    下一篇

α-硫羰基膦酸衍生化喹唑啉酮含磷类似物的研究

黄君珉, 陈茹玉   

  1. 南开大学元素有机化学研究所, 南开大学元素有机化学国家重点实验室, 天津 300071
  • 收稿日期:1999-10-26 出版日期:2000-08-24 发布日期:2000-08-24
  • 通讯作者: 黄君珉(1971年出生),男,博士,从事杂原子有机化学研究.E-mail:jmhuang@public.tpt.tj.cn E-mail:jmhuang@public.tpt.tj.cn
  • 基金资助:

    国家自然科学基金(批准号:29972021)

Studies of α- Thiocarbonyl Phosphonic Acid Derivative Quinazolone Analogues Containing Phosphorus

HUANG Jun-Min, CHEN Ru-Yu   

  1. Institute of Elemento Organic Chemistry, National Laboratory of Elemento Organic Chemistry, Nankai University, Tianjin 300071, China
  • Received:1999-10-26 Online:2000-08-24 Published:2000-08-24

摘要: 研究了两种不同的合成路线,合成17个新的α-硫羰基膦酸衍生化喹唑啉酮含磷类似物2a~2q,其结构经NMR,IR,MS和元素分析表征.通过单晶X射线衍射分析,探讨了稠杂环标题化合物的立体化学特征,并对其1,3位取代基的氢谱磁不等价现象进行了合理解释.初步生物活性测试结果表明,部分标题结构的化合物具有良好的植物激素活性.

关键词: &alpha, -硫羰基膦酸, 喹唑啉酮含磷类似物, 反应, 立体化学, 生物活性

Abstract: Aseries of N-substituted 1-methoxycarbonylmethyl-3-substituted-2,4-dioxo-1,3,2-benzodiazaphosphorin-2-carboxamides(2a_2q) have been designed and synthesized by two methods, and their structures were confirmed by elemental analysis, NMR, IRand MS. On the basis of X-ray diffraction analysis, we discussed stereochemistry of the title compounds, and studied their 1H NMRmagnetic nonequivalent phenomenon which agrees with the results of X-ray analysis. The preliminary bioassay shows that some of the title compounds have a good plant hormone activity.

Key words: α-Thiocarbonyl phosphonic acid, Quinazolone analogues containing phosphorus, Reaction, Stereochemistry, Biological activity

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