高等学校化学学报 ›› 1996, Vol. 17 ›› Issue (3): 396.

• 论文 • 上一篇    下一篇

有机阴离子的人工接受体的合成

陆国元, 何卫江, 胡宏纹   

  1. 南京大学化学系, 南京 210093
  • 收稿日期:1995-03-31 出版日期:1996-03-24 发布日期:1996-03-24
  • 通讯作者: 陆国元,男,49岁,副教授.
  • 作者简介:陆国元,男,49岁,副教授.
  • 基金资助:

    国家自然科学基金

Synthesis of Artificial Receptor of Organic Anion

LU Guo-Yuan, HE Wei-Jiang, HU Hong-Wen   

  1. Department of Chemistry, Nanjing University, Nanjing 210093
  • Received:1995-03-31 Online:1996-03-24 Published:1996-03-24

摘要: 报道以D-天冬酰胺为起始原料经9步反应合成旋光活性的(2R,8R)-二羟甲基-1,5,9-三氮双环[4.4.0]癸-9-烯盐酸盐,总产率为25.4%.

关键词: 阴离子, 接受体, 合成

Abstract: The optically active(2R,8R)-bis(hydroxymethyl)-1,5,9-triazabicyclo[4.4.0]dec-9-ene has been synthesized from D-asparaginate with a total yield of 25.4%.In the synthesis,the key intermediate is a thiourea derivative from reduction and coupling of the starting materials and the key reaction is it's methylation and double SNreaction to form bicyclic skeleton.Amino and hydroxy are protected by tosyl and silyl groups which can be cleaved under very mild conditions respectively.The target molecule is a useful intermediate in the construction of chiral and selective receptors of organic anions.

Key words: Anion, Receptor, Synthesis

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