高等学校化学学报

高等学校化学学报 ›› 1996, Vol. 17 ›› Issue (12): 1869.

• 论文 • 上一篇    下一篇

具有生物活性的有机磷化合物研究(XII)──α-(苯并噁唑-2-氧乙酰氧基)烃基膦酸酯的合成和性质

胡利明, 贺红武, 刘钊杰   

  1. 华中师范大学有机合成研究所, 武汉, 430070
  • 收稿日期:1995-12-12 出版日期:1996-12-24 发布日期:1996-12-24
  • 通讯作者: 刘钊杰
  • 作者简介:胡利明,男,32岁,硕士,讲师.
  • 基金资助:

    国家自然科学基金;湖北省自然科学基金

Strdies on Biological Active Organophosphorus Compounds(XII)──Synthesis and Property of α-(2-Benzoxazolyl)oxyacetoxyalkyl Phosphonates

HU Li-Ming, HE Hong-Wu, LIU Zhao-Jie   

  1. Institute of Organic Synthesis, Central China Normal University, Wuhan, 430070
  • Received:1995-12-12 Online:1996-12-24 Published:1996-12-24

PDF (PC)

摘要： 通过3-羟甲基苯并唑酮与金属钠的反应制取其钠盐,利用钠盐同α-氯代乙酰氧基烃基膦酸酯反应合成21个未见报道的α-(苯并唑-2-氧乙酰氧基)烃基膦酸酯类化合物,确定了产物的结构,考察了反应条件,探讨了可能的反应机理。

关键词: 3-羟甲基苯并唑酮, 合成, 反应机理, 分子内电子转移重排

Abstract: Twenty-one new phosphorus compounds were synthesized by the reaction of O,O-dialkyl-α-chloroacetoxyalkyl phosphonates and sodium salt of 3-hydroxymethylbenzoxazolone.Their structures were confirmed by means of elementary analysis,IR,1H and 31P NMR and MS.The possible mechanism is that the unsteady reactive intermediate reacting from reactants undergoes intramolecular electron migration rearrangement to form the products.

Key words: 3-Hydroxymethylbenzoxazolone, Synthesis, Reaction mechanism, Intramolecular electron migration rearrangement

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