Synthesis of Phosphatidyl Ethanolamine Polyphosphate Liposomal Materials

Abstract

Abstract: Four phosphatidyl ethanolamine polyphosphates were prepared by polycondensation of β-chloroethyl dichlorophosphate and pentaerythritol di-fatty acid esters in benzene,and then by aminatlon with ammonia. Liposomes were prepared with these amphiphilicpolymers according to REVmethod. All materials could form large unilamellar vesicles (LUV)detected by polarized optical microscope and electron microscope. Encapsulation efficienciesof liposome (Ⅱa-Ⅱd) to 5-fluorouracil and release rate of liposome were determined.

Key words: Polyphosphate, Liposome, Large unilamellar vesicles, Drug release

CLC Number:

O634.5

TrendMD:

LIU Zhen-Hua, CHEN Mao, FAN Chang-Lie, ZHANG Jie, ZHUO Ren-Xi. Synthesis of Phosphatidyl Ethanolamine Polyphosphate Liposomal Materials[J]. Chem. J. Chinese Universities, 1997, 18(9): 1556.

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Synthesis of Phosphatidyl Ethanolamine Polyphosphate Liposomal Materials

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