Synthesis and Characterization of Injectable Hydrogels Based on Star β-CD-g-poly(L-glutamic acid)

doi:10.7503/cjcu20170008

Chem. J. Chinese Universities ›› 2017, Vol. 38 ›› Issue (8): 1489.doi: 10.7503/cjcu20170008

• Polymer Chemistry • Previous Articles Next Articles

Synthesis and Characterization of Injectable Hydrogels Based on Star β-CD-g-poly(L-glutamic acid)

JIAN Yuhang, YAN Shifeng, LI Xing, HUANG Yanan, YIN Jingbo

Department of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Shanghai 200444, China

Received:2017-01-05 Revised:2017-05-03 Online:2017-08-10 Published:2017-05-03
Supported by:
Supported by the National Natural Science Foundation of China(Nos. 51473090, 51373094), the Natural Science Foundation of Shanghai City, China(No. 14ZR1414600) and the Science and Technology Commission of Shanghai Municipality, China(No. 15JC1490400).

Abstract

Abstract:

A Gadelle-Defaye method was used to synthesis per-6-amino-β-CD[β-CD-(NH₂)₇]. Then, different molecular weighted star β-CD-g-poly(L-glutamic acid)(β-CD-g-PLGA-ADH) was synthesised via "grafting-from" method. The hydrogel precursors, β-CD-g-PLGA-ADH and oxided alginate(ALG-CHO) were mixed to prepare β-CD-g-PLGA/ALG hydrogel. The effect of solid content and molecular weight of β-CD-g-PLGA on the properties of hydrogel was studied. Simvastatin(SIM) was used as a model drug, the drug loading and release behavior of β-CD-g-PLGA/ALG hydrogel were researched. The introduction of β-CD into hydrogel made it an effective SIM loading and sustained release system.

Key words: Injectable hydrogel, β-Cyclodextrin, Poly(L-glutamic acid), Sustained drug release

CLC Number:

O636

TrendMD:

JIAN Yuhang, YAN Shifeng, LI Xing, HUANG Yanan, YIN Jingbo. Synthesis and Characterization of Injectable Hydrogels Based on Star β-CD-g-poly(L-glutamic acid)[J]. Chem. J. Chinese Universities, 2017, 38(8): 1489.

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Synthesis and Characterization of Injectable Hydrogels Based on Star β-CD-g-poly(L-glutamic acid)

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