Chem. J. Chinese Universities ›› 2018, Vol. 39 ›› Issue (4): 817.doi: 10.7503/cjcu20170541
• Polymer Chemistry • Previous Articles Next Articles
Received:
2017-08-07
Online:
2018-04-10
Published:
2018-01-02
Contact:
JIA Yuxi
E-mail:jia_yuxi@sdu.edu.cn
Supported by:
TrendMD:
YE Hui, LIU Yabo, JIA Yuxi. Numerical Simulation of Swelling and Drug Release Processes for Weak Polyelectrolyte Hydrogels†[J]. Chem. J. Chinese Universities, 2018, 39(4): 817.
Reference object | Parameter | Value |
---|---|---|
Free ions | Diffusion coefficient, Di/(m2·s-1) | 1×1 |
Drugs | Initial concentration, cd0/(kg·m-3) | 1.264 |
Solution | Viscosity, η/(Pa·s) | 1×10-3 |
Fluid pressure, p0 | 0 | |
Electric potential, ψ0 | 0 | |
Polymer network | Initial volume fraction of water, ϕw0 | 0.8 |
Initial concentration of fixed charge, cf0/(mmol·L-1) | 2.12 |
Table 1 Material parameters and values
Reference object | Parameter | Value |
---|---|---|
Free ions | Diffusion coefficient, Di/(m2·s-1) | 1×1 |
Drugs | Initial concentration, cd0/(kg·m-3) | 1.264 |
Solution | Viscosity, η/(Pa·s) | 1×10-3 |
Fluid pressure, p0 | 0 | |
Electric potential, ψ0 | 0 | |
Polymer network | Initial volume fraction of water, ϕw0 | 0.8 |
Initial concentration of fixed charge, cf0/(mmol·L-1) | 2.12 |
Diffusive type | n | Control step of drug release |
---|---|---|
Case Ⅰ diffusion(Fickian diffusion) | 0.45 | Drug diffusion |
Case Ⅱ diffusion(Relaxation diffusion) | 0.89 | Polymer relaxation |
Case Ⅲ diffusion(Anomalous diffusion) | 0.45-0.89 | Drug diffusion and polymer relaxation |
Table 2 Exponential relation of drug release ratio to time
Diffusive type | n | Control step of drug release |
---|---|---|
Case Ⅰ diffusion(Fickian diffusion) | 0.45 | Drug diffusion |
Case Ⅱ diffusion(Relaxation diffusion) | 0.89 | Polymer relaxation |
Case Ⅲ diffusion(Anomalous diffusion) | 0.45-0.89 | Drug diffusion and polymer relaxation |
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