Synthesis and Antitumor Activity of Polyphosphate Ester Containing Hexestrol

Chem. J. Chinese Universities ›› 1994, Vol. 15 ›› Issue (7): 1090.

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Synthesis and Antitumor Activity of Polyphosphate Ester Containing Hexestrol

LUO Yi, ZHUO Ren-Xi, FAN Chang-Lie

Department of Chemistry, Wuhan University, Wuhan, 430072

Received:1993-07-08 Revised:1993-11-23 Online:1994-07-24 Published:1994-07-24

Abstract

Abstract: Three biodegradable polyphosphate esters were synthesized by polycondensation of hexestrol with dichlorophosphoric acid ethyl ester, dichlorophosphonoformic acid ethyl ester or dichlorophosphonoacetic acid ethyl ester.The structures of these polymers were confirmed by IR, ¹H NMR and elementary analysis.The release testing was carried out in different pHmedia.The in vitro antitumor activity data showed that this kind of polyphosphate ester as polymeric prodrugs exhibits a good antitumor activity against EAC cells.

Key words: Hexestrol, Polyphosphate ester, Antitumor activity

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LUO Yi, ZHUO Ren-Xi, FAN Chang-Lie. Synthesis and Antitumor Activity of Polyphosphate Ester Containing Hexestrol[J]. Chem. J. Chinese Universities, 1994, 15(7): 1090.

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Synthesis and Antitumor Activity of Polyphosphate Ester Containing Hexestrol

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