Studies on the Synthesis and Antitumor Activity of 3-Aminopropylsilatrane Derivatives

Abstract

Abstract: Fourteen new derivatives of 3-aminopropylsilatrane were synthesized by the reaction of 3-aminopropylsilatrane with acids or 3-chloropropylsilatrane with amines.The structures of these compounds were identified with ¹H NMR, IRand elemental analysis.The results of in vitro cell culture testing showed that some of the silatrane derivatives exhibit good antitumor activity.

Key words: Antitumor activity, 2,8,9-Trioxa-5-aza-1-silabicyclo[3,3,3]undecane, 3-Aminopropyl-2,9-trioxa-5-aza-1-silabicyclo[3,3,3]undecane, 3-Chloropropyl-2,9-trioxa-5-aza-1-silabicy-clo[3,3,3]undecane

TrendMD:

Ding Qizhu, Luo Xuangan, Zhuo Renxi . Studies on the Synthesis and Antitumor Activity of 3-Aminopropylsilatrane Derivatives[J]. Chem. J. Chinese Universities, 1989, 10(10): 1007.

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Studies on the Synthesis and Antitumor Activity of 3-Aminopropylsilatrane Derivatives

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