高等学校化学学报

高等学校化学学报 ›› 1994, Vol. 15 ›› Issue (10): 1494.

• 研究简报 • 上一篇    下一篇

胆汁酸选择脱氧的新方法

李开喜, 徐正邦, 余锐, 赵华明   

  1. 四川大学化学系, 成都, 610064
  • 收稿日期:1993-10-16 修回日期:1994-08-03 出版日期:1994-10-24 发布日期:1994-10-24
  • 通讯作者: 徐正邦.
  • 作者简介:李开喜,男,27岁,硕士,讲师.
  • 基金资助:

    国家自然科学基金

A New Approach to Selective Deoxygenation of Bile Acids

LIKai-Xi, XU Zheng-Bang, YU Rui, ZHAO Hua-Ming   

  1. Department of Chemistry, Sichuan University, Chengdu, 610064
  • Received:1993-10-16 Revised:1994-08-03 Online:1994-10-24 Published:1994-10-24

PDF (PC)

关键词: 胆汁酸, 冠醚, 钾, 脱氧反应, 自由基

Abstract: Selective deoxygenation of four bile acids with K/18-Crown-6/But NH2 was first reported.It can be accomplished by four steps:methylesterification, diacylation or selective diacylation, selective hydrolysis and reduction.The products formed in formal three steps were not isolated(not necessary).The last step is carried out rapidly at room temperature, with a little by-product.The present approach is straight forward, practicable and with high over all yields, 70% 75%.

Key words: Bile acids, Crown ether, Potassium, Deoxygenation, Radical

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