高等学校化学学报

高等学校化学学报 ›› 2005, Vol. 26 ›› Issue (12): 2241.

• 研究论文 • 上一篇    下一篇

硝基苯并咪唑衍生物的合成、表征及抑菌活性的测定

王陆瑶,高勇,杨秉勤,史真   

  1. 西北大学化学系,西安710069
  • 收稿日期:2004-11-24 出版日期:1905-03-14 发布日期:1905-03-14
  • 通讯作者: 史真(1948年出生),男,教授,博士生导师,从事有机合成研究.E-mail:shizhen@nwu.edu.cn
  • 基金资助:

    国家自然科学基金(批准号：20472067)资助.

Synthesis, Structure and Bioactivity of Nitrobenzoimidazole Derivatives

WANG Lu-Yao, GAO Yong, YANG Bing-Qin, SHI Zhen*   

  1. Department of Chemistry, Northwest University, Xi′an 710069, China
  • Received:2004-11-24 Online:1905-03-14 Published:1905-03-14
  • Contact: SHI Zhen;E-mail:shizhen@nwu.edu.cn

被引次数

80

摘要：

以苯并咪唑为原料，经硝化、二茂铁磺酰化等步骤，合成了8种未见文献报道的硝基苯并咪唑衍生物,其结构经MS，1H NMR和元素分析确证.由于硝基苯并咪唑的互变异构,二茂铁磺酰化后，产生两个异构体,用X射线衍射仪测定了化合物2a的晶体结构.初步的抑菌实验结果表明,该系列化合物具有良好的抑菌作用，其抑菌活性均优于对照药剂50%多菌灵可湿性粉剂.

关键词: 硝基苯并咪唑; 合成;晶体结构;生物活性, 硝基苯并咪唑, 合成, 晶体结构, 生物活性

Abstract:

It was reported that benzoimidazole and ferrocene compounds maybe exhibit high pharmaceutical functions. Eight new nitrobenzoimidazole derivatives were prepared by the reaction of ferrocene sulfonylchloride with 5-nitrobenzoimidazole and characterized by means of elemental analysis, MS and 1H NMR. The structure of the new compounds was further confirmed by X-ray crystallograghic analysis as exemplified by compounds 3b. The activities of compounds 3a-4d were evaluated against five fungicides. Compared with carbendazim(50% wet powder), better inhibitory activities were observed for these synthesized compounds.

Key words: Nitrobenzoimidazole; Synthesis; Crystal structure; Antimicrobial activity, Nitrobenzoimidazole, Synthesis, Crystal structure, Antimicrobial activity

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