高等学校化学学报 ›› 2004, Vol. 25 ›› Issue (9): 1604.

• 研究论文 • 上一篇    下一篇

水杨酸键联卟啉的合成及与牛血清白蛋白的相互作用

贾涛1, 王凯1,2, 鲍小平1, 赵一玫3, 李早英1   

  1. 1. 武汉大学化学与分子科学学院, 武汉430072;
    2. 武汉化工学院化工与制药系, 武汉430074;
    3. 红桃K集团股份有限公司研究院, 武汉430070
  • 收稿日期:2003-11-11 出版日期:2004-09-24 发布日期:2004-09-24
  • 基金资助:

    国家自然科学基金(批准号:29972035);武汉大学自强科学基金(2000年)资助

Synthesis of Metal Porphyrins Bonded with Salicylic Acid and Their Interaction with Bovine Serum Albumin

JIA Tao1, WANG Kai1,2, BAO Xiao-Ping1, ZHAO Yi-Mei3, LI Zao-Ying1   

  1. 1. College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, China;
    2. Department of Pharmaceutical Technology, Wuhan Institute of Chemical Techology, Wuhan 430074, China;
    3. Institute of RHK(Group) Co. Ltd., Wuhan 430070, China
  • Received:2003-11-11 Online:2004-09-24 Published:2004-09-24

摘要: 以溴代烷氧基苯基卟啉(1)为原料与水杨酸作用,分别得到了化合物2和3,再与醋酸钴反应,得到了钴卟啉配合物4和5.新化合物分别由1HNMR,IR,UV-Vis,MS和元素分析确证.同时,利用荧光光谱考察了金属卟啉与牛血清白蛋白的相互作用.

关键词: 金属卟啉, 水杨酸, 合成, 牛血清白蛋白, 荧光光谱

Abstract: A synthetic method of porphyrins bonded with salicylic substituents was described. Reaction of bromoalkoxyphenyl porphyrin(1) with salicylic acid gave free porphyrins 2 and 3. Treatment of porphyrins 2 and 3 with Co(OCOCH3)2 respectively, afforded metalloporphyrins 4 and 5. These new compounds were confirmed by 1H NMR, IR, UV-Vis, MS and elemental analysis, and their interaction with bovine serum albumin(BSA) in fluorescence spectrum was observed.

Key words: Metalloporphyrin, Salicylic acid, Synthesis, Bovine serum albumin(BSA), Fluorescence spectrum

中图分类号: 

TrendMD: