12-钨硼酸5-氟尿嘧啶盐的合成及抗癌活性研究

高等学校化学学报 ›› 2004, Vol. 25 ›› Issue (6): 1010.

12-钨硼酸5-氟尿嘧啶盐的合成及抗癌活性研究

李娟^1,2, 李静², 齐燕飞¹, 王宏芳², 王恩波¹, 胡长文¹, 许林¹, 吴新宇²

1. 东北师范大学化学学院多酸化学研究所, 长春 130024;
2. 吉林大学公共卫生学院, 长春 130021

收稿日期:2003-09-24 出版日期:2004-06-24 发布日期:2004-06-24
通讯作者: 王恩波(1936年出生),男,教授,博士生导师,从事多酸化学研究.E-mail:wangenbo@public.cc.j.lcn E-mail:wangenbo@public.cc.j.lcn
基金资助:
国家自然科学基金(批准号:20171010)资助

Synthesis and Anti-liver Cancer Activity of 5-Fluorouracil Salt of 12-Tungstoboric Acid

LI Juan^1,2, LI Jing², QI Yan-Fei¹, WANG Hong-Fang², WANG En-Bo¹, HU Chang-Wen¹, XU Lin¹, WU Xin-Yu²

1. Institute of Polyoxometalate Chemistry, Faculty of Chemistry, Northeast Normal University, Changchun 130024, China;
2. School of Public Health, Jilin University, Changchun 130021, China

Received:2003-09-24 Online:2004-06-24 Published:2004-06-24

摘要/Abstract

摘要： 5-氟尿嘧啶(5-Fu)是一种阻止肿瘤细胞嘧啶类核苷酸合成的抗代谢药物,对多种肿瘤有较好的疗效.但该药首次代谢效应显著,毒副作用较大,且治疗剂量与中毒剂量接近,使其临床应用受到一定限制.为降低毒性,提高其活性,人们从多方面对5-Fu进行化学修饰,设计合成出许多新药^[1～4].近年来,多金属氧酸盐因结构独特,在抗病毒、抗肿瘤等方面的应用已引起人们的广泛重视^[5～7].王晓红等^[8,9]曾先后报道了杂多钨酸盐的体内、外抗肿瘤活性.多金属氧酸具有较强的接受电子的能力^[10],能与含有N,S和O原子的有机基质作用形成新型化合物^[11～14].

关键词: 钨硼酸, 5-氟尿嘧啶, 合成, 抗癌活性

Abstract: 5-Fluorouracil salt(WBF) of 12-tungstoboric acid with Keggin structure was synthesized and its structure was characterized by IR, ¹H NMR, ¹⁸³ W NMR and elementary analysis. The MTT experimental results show that WBF has a stronger killing ability for liver cancer cells in vitro. The acute toxicity of WBF was carried out. The half toxicity dose LD₅₀ of WBF orally administrated to mice is 1 117.4 mg/kg.

Key words: Tungstoboric acid, 5-Fluorouracil, Synthesis, Anti-liver cancer activity

中图分类号:

O614

TrendMD:

李娟, 李静, 齐燕飞, 王宏芳, 王恩波, 胡长文, 许林, 吴新宇. 12-钨硼酸5-氟尿嘧啶盐的合成及抗癌活性研究. 高等学校化学学报, 2004, 25(6): 1010.

LI Juan, LI Jing, QI Yan-Fei, WANG Hong-Fang, WANG En-Bo, HU Chang-Wen, XU Lin, WU Xin-Yu. Synthesis and Anti-liver Cancer Activity of 5-Fluorouracil Salt of 12-Tungstoboric Acid. Chem. J. Chinese Universities, 2004, 25(6): 1010.

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