高等学校化学学报 ›› 2004, Vol. 25 ›› Issue (11): 2024-2027.

• 研究论文 • 上一篇    下一篇

1-(取代吡唑-4-甲酰基)吡唑类化合物的合成及生物活性研究

程永浩, 邹小毛, 高颖, 杨华铮   

  1. 南开大学元素有机化学研究所, 元素有机化学国家重点实验室, 天津300071
  • 收稿日期:2003-10-07 出版日期:2004-11-24 发布日期:2004-11-24
  • 基金资助:

    国家自然科学基金(批准号:20172031);教育部博士学科点专项基金资助

Synthesis and Biological Activity of Novel 1-(Substituted-pyrazole-4-carbonyl) Pyrazoles

CHENG Yong-Hao, ZOU Xiao-Mao, GAO Ying, YANG Hua-Zheng   

  1. State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
  • Received:2003-10-07 Online:2004-11-24 Published:2004-11-24

摘要: 设计合成了25个新型1-取代吡唑甲酰基吡唑系列衍生物,化合物结构经1HNMR、元素分析、IR和MS确证.生物活性测试结果表明,该类化合物具有一定除草活性,讨论了其结构与活性的关系.

关键词: HPPD抑制剂, 合成, 吡唑, 生物活性, 构效关系

Abstract: A series of new 1-(substituted-pyrazole-4-carbonyl)-pyrazoles were synthesized by the reaction of 5-amino-1-methyl-3-(methylthio)-1H-pyrazole-4-carbohydrazide and 5-amino-1-methyl-1H-pyrazole-4-carbohydrazide respectively with 2-cyano-3,3-bis(alkylthio) acrylates or 2-[bis(alkylthio)methylene] malononitriles. All the compounds were structurally confirmed by elemental analysis and 1H NMR. Their herbicidal activities were tested. Bioassay results showed that some of them had herbicidal activities. The structure-activity relationship was discussed, which indicated the substituents on the pyrazole ring have influence on the title compounds activities.

Key words: HPPD inhibitor, Synthesis, Pyrazole, Biological activity, Structure-activity relationship

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