高等学校化学学报

高等学校化学学报 ›› 2003, Vol. 24 ›› Issue (8): 1419.

• 论文 • 上一篇    下一篇

手性Boc保护氨基酸修饰卟啉的合成及谱学研究

赵小菁, 阮文娟, 张玉玲, 韩华, 朱志昂   

  1. 南开大学化学系, 天津 300071
  • 收稿日期:2002-07-18 出版日期:2003-08-24 发布日期:2003-08-24
  • 通讯作者: 阮文娟(1958年出生),女,博士,副教授,从事分子识别及不对称催化研究.E-mail:wjrudn@nanka.iedu.cn E-mail:wjrudn@nanka.iedu.cn
  • 基金资助:

    国家自然科学基金(批准号:20171024);天津市自然科学基金(批准号:023604011);教育部留学回国人员科研基金资助

Synthesis and Spectrum of Chiral Boc Protected Amino Acids Linked Porphyrins

ZHAO Xiao-Jing, RUAN Wen-Juan, ZHANG Yu-Ling, HAN Hua, ZHU Zhi-Ang   

  1. Department of Chemistry, Nankai University, Tianjin 300071, China
  • Received:2002-07-18 Online:2003-08-24 Published:2003-08-24

PDF (PC)

被引次数

11

摘要： 合成了α,α,α,β-四-[邻(叔丁氧羰丙氨酸)氨基苯基]卟啉H2T(o-BocAla)APP(1)及其锌()配合物ZnT(o-BocAla)APP(Zn-1),α,α,α,β-四-[邻(叔丁氧羰苏氨酸)氨基苯基]卟啉H2T(o-BocThr)APP(2)及其锌(Ⅱ)配合物ZnT(o-BocThr)APP(Zn-2),α,α,α,β-四-[邻(叔丁氧羰酪氨酸)氨基苯基]卟啉H2T(o-BocTyr)APP(3)及其锌()配合物ZnT(o-BocTyr)APP(Zn-3)等6种叔丁氧羰保护氨基酸修饰的卟啉.用元素分析、核磁共振、红外光谱、紫外-可见光谱以及圆二色谱等手段对其组成的结构进行了表征,并对其谱学性质进行了研究.

关键词: 手性Boc保护氨基酸修饰卟啉, 合成, 性质, 圆二色谱(CD)

Abstract: Meso-tetrakis(o-BocAlamido) porphyrin [H2T(o-BocAla)APP, 1] and its zinc complex [ZnT(o-BocAla)APP, Zn-1, meso-tetrakis(o-BocThrmido)porphyrin [H2To-ocAls)APP, and its zinc complex [ZnT(o-BocThr)APP, Zn-2 , meso-tetrakis(o-BocTyrmido) porphyrin [H2T(o-BocTyr)APP, 3and its zinc complex [ZnT(o-BocTyr)APP, Zn-3] were synthesized and characterized by elemental analyses, FTIR, 1HNMR, UV-Vis and CD.The FTIRspectra and 1HNMR of these complexes were compared and discussed.The UV-Vis and CDspectra of complexes were also attributed and minutely discussed.Compared with ZnTPP, the bands of porphyrins 1, 2, 3 have visibly red-shifts.Obviously, the cotton signals of 1 and 2, 3 are opposite, maybe it was caused by hydroxyl group.

Key words: Chiral amino acids linked porphyrin, Synthesis, Property, Circular dichroism

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