高等学校化学学报

高等学校化学学报 ›› 2003, Vol. 24 ›› Issue (8): 1414.

• 论文 • 上一篇    下一篇

4个天然1,7-二芳基庚烷类化合物的合成

李绍白, 刘运根, 朱明钊   

  1. 兰州大学化学化工学院, 应用有机化学国家重点实验室, 兰州 730000
  • 收稿日期:2002-07-18 出版日期:2003-08-24 发布日期:2003-08-24
  • 通讯作者: 李绍白(1946年出生),男,教授,从事有机合成研究.E-mail:bsli@lzu.edu.cn E-mail:bsli@lzu.edu.cn
  • 基金资助:

    兰州大学应用有机化学国家重点实验室开放基金资助

Studies on the Synthesis of Four Natural1,7-Diarylheptanoids

LI Shao-Bai, LIU Yun-Gen, ZHU Ming-Zhao   

  1. National Laboratory of Applidied Organic Chemistry, Lanzhou University, Lanzhou 730000, China
  • Received:2002-07-18 Online:2003-08-24 Published:2003-08-24

PDF (PC)

被引次数

7

摘要： 合成了4个天然1,7-二芳基庚烷类化合物:1-(4′-羟基-3′-甲氧基苯基)-7-(4″-羟基苯基)-5-羟基-3-庚酮(1),1-(4′-羟基-3′-甲氧基苯基)-7-(4″-羟基苯基)-4-庚烯-3-酮(2),1-(3′,4′-二羟基苯基)-7-(4″-羟基苯基)-5-羟基-3-庚酮(3),1-(3′,4′-二羟基苯基)-7-(4″-羟基苯基)-4-庚烯-3-酮(4).化合物1,2,4为首次合成.

关键词: 二芳基庚烷类化合物, 天然化合物, 合成

Abstract: Diarylheptanoids constitute a distinct group of metabolites of natural plant characterized by two aromatic rings linked by a linear seven aliphatic chain.There have been few reports on the biological activities of diarylheptanoids, most of which appearing in the areas of anti-inflammatory, anti-oxidative, superoxide scavenging and anti-hepatotoxic effects.Some of them are used as traditional medicine in Asia.Compounds 1 and 2 were firstly isolated from the rhizomes of Zingiber offical respectively.1-(3′,4′-Dihydroxyphenyl)-7-(4″-hydroxyphenyl)-4-hepten-3-one(4) was firstly isolated from the flowers of A.japonica.Herein, we report the synthesis of these four natural1,7-diarylheptanoids, 5-hydroxy-1-(4′-hydroxy-3′-methoxyphenyl)-7-(4″-hydroxyphenyl)-3-heptanone (1), 1-(4′-hydroxy-3′-methoxyphenyl)-7-(4″-hydroxyphenyl)hept-4-en-3-one (2)(Gingerenone C), 5-hydroxy-1-(3′,4′-dihydroxyphenyl)-7-(4″-hydroxyphenyl)-3-heptanone (3) and 1-(3′,4′-dihydroxyphenyl)-7-(4″-hydroxyphenyl)hept-4-en-3-one (4).And compounds 1, 2 and 4 were firstly synthesized.

Key words: Diarylheptanoids, Natural compound, Synthesis

中图分类号: 

TrendMD: