高等学校化学学报

高等学校化学学报 ›› 2002, Vol. 23 ›› Issue (12): 2284.

• 研究简报 • 上一篇    下一篇

2',3'-乙氧甲撑基腺苷5'-硫代磷酰氨基酸酯的合成和谱学分析

苗志伟1, 冯玉萍1, 付华1, 涂光忠2, 赵玉芬1   

  1. 1. 清华大学化学系, 教育部生命有机磷化学重点实验室, 北京100084;
    2. 北京微量化学研究所, 北京100091
  • 收稿日期:2001-10-24 出版日期:2002-12-24 发布日期:2002-12-24
  • 通讯作者: 赵玉芬(1948年出生),女,博士,教授,博士生导师,中国科学院院士,主要从事生命有机磷化学研究.E-mail:t p-dch@t s inghua.edu.cn E-mail:tp-dch@tsinghua.edu.cn
  • 基金资助:

    国家自然科学基金(批准号:29902003,39870415);清华大学博士生创新基金(批准号:092430305)资助

Synthesis and Spectroscopic Analysis of 2',3'-O-Ethoxymethylidene Adenosine 5'-Thiophosphoramidates

MIAO Zhi-Wei1, FENG Yu-Ping1, FU Hua1, TU Guang-Zhong2, ZHAO Yu-Fen1   

  1. 1. The Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China;
    2. Beijing Institute of Microchemistry, Beijing 100091, China
  • Received:2001-10-24 Online:2002-12-24 Published:2002-12-24

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关键词: 2', 3'-乙氧甲撑基腺苷5'-硫代磷酰氨基酸酯, 合成, 谱学分析

Abstract: Nucleoside reverse transcriptase inhibitors are the only drugs so far approved for the treatment of AIDS. Several nucleoside analogs are potent inhibitors of human immunodeficiency virus(HIV) in cell culture. However, in many cases the nucleoside derivatives have a poor affinity for nucleoside kinases. Nucleoside 5'-phosphorothioates is relatively resistant to enzymatic transformations. In this paper, 2',3'-O-alkoxymethylidene adenosine 5'-thiophosphoramidates were synthesized through a highly efficient approach. The new compounds were characterized by NMR, IR and ESI-MS.

Key words: O-Ethoxymethylidene adenosine 5'-thiophosphoramidate, Synthesis, Spectroscopic analysis

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