高等学校化学学报 ›› 2001, Vol. 22 ›› Issue (12): 2037.

• 研究简报 • 上一篇    下一篇

一步法立体专一性合成游离β-吡喃糖碳苷

王文忠1, 张佩瑛2, 吕以仙2   

  1. 1. 华北煤炭医学院药学系, 唐山 063000;
    2. 北京大学药学院化学生物学系, 北京 100083
  • 收稿日期:2000-09-04 出版日期:2001-12-24 发布日期:2001-12-24
  • 通讯作者: 吕以仙(1939年出生),女,教授,从事碳苷研究.E-mail:luyixian@2631net E-mail:luyixian@2631net
  • 基金资助:

    国家自然科学基金(批准号:29472034)资助

Stereospecific Synthesis of Free Hydroxyl β-C-Glycosides in One Sstep

WANG Wen Zhong1, ZHANG PeiYing2, Lü YiXian2   

  1. 1. Departmentof Pharmacy, North China Coal Medical College, Tangshan 063000, China;
    2. Departmentof Chemical Biology, Schoolof Pharmaceutical Sciences, Peking University, Beijing 100083, China
  • Received:2000-09-04 Online:2001-12-24 Published:2001-12-24

关键词: 碳苷, 合成, Wittig-Horner反应

Abstract: Free aldopentoses and aldohexoses reacted respectively with (EtO)2P(O)CHNaCOAr to give the five stereospecific free hydroxyl β Cglycosides in one step. The reaction take place under a mild condition. The procedures are simple and convenient. The prices of starting materials are cheap. The method can be applied universally for aldopentoses and aldohexoses. The application scope of Wittig Horner reaction has also been expanded. The synthesis of free hydroxyl β Cglycosides from free aldoses directly using WittingHorner reaction has not been reported so far.

Key words: C glycosides, Synthesis, Wittig Horner reaction

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