高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (12): 1791.

• 论文 •    下一篇

Keggin结构钼锗稀土杂多蓝的合成性质及抗病毒活性研究

刘杰1, 张黔玲1, 王丽君2, 王恩波3, 黄锦汪1, 计亮年1   

  1. 1. 超速激光光谱国家重点实验室, 中山大学化学化工学院, 广州 510275;
    2. 吉林医学院, 吉林 132001;
    3. 东北师范大学化学系, 长春 130024
  • 收稿日期:1999-10-11 出版日期:2000-12-24 发布日期:2000-12-24
  • 通讯作者: 刘　杰(1964年出生),女,博士,从事配合物的合成及药物化学研究.
  • 基金资助:

    国家自然科学基金(批准号:39870895)资助.

Synthesis, Properties and Antiviral Activity of Keggin Molybdogemnium Heteropoly Blues

LIU Jie1, ZHANG Qian-Ling1, WANG Li-Jun-WANG En-Bo2, HUANG Jin-Wang3, JI Liang-Nian1   

  1. 1. State Key Laboratoryof Ultrafast Laser Spectroscopy, Departmentof Chemistry, Zhongshan University, Guang zhou 510275, China;
    2. Jilin Medical University, Jilin 132001, China;
    3. Department of Chemistry, Northeast Normal University, Changchun 130024, China
  • Received:1999-10-11 Online:2000-12-24 Published:2000-12-24

PDF (PC)

被引次数

46

摘要： 采用电解法合成了一系列Keggin结构钼锗稀土二电子LnH3[GeMo12O40]·nH2O和四电子LnH5[GeMo12O40]·nH2O杂多蓝(Ln=La,Ce,Pr,Nd,Sm,Eu,Gd).通过IR,UV-Vis,DTA,XPS和ESR等方法对产物进行了表征,确认杂多蓝仍保持Keggin结构,但结构有轻微的畸变.研究了Pr(2)对小鼠感染FM1的治疗效果,并与阳性对照药物病毒唑作了比较.结果表明,Pr(2)具有很好的抗病毒活性,甚至超过阳性对照药物病毒唑的抗病毒效果,比较两种给药途径,结果发现,腹腔注射优于口服给药的抗病毒效果

关键词: 稀土元素, 杂多蓝, 合成, 性质, 抗病毒活性

Abstract: Rare earth molybodogemanium 2e, 4e heteropoly blues, LnH3[GeMo10ⅥMo2ⅤO40]·8H2Oand LnH5[GeMo8ⅥMo4ⅤO40]·8H2O(Ln=La, Ce, Nd, Sm, Gd), have been prepared and characterized by IR, UV, TG DTA, XPS, ESR.It is found that the structures of the heteropoly blues still retain the Keggin structure with a slight difference compared with their un reduced compounds.The in vivo activity of Pr(2) against influenza virus(FM1) in the mice was investigated.Pr(2) was administrated perorally(po) and intraperitoneally(i.p) to 14-16 g Kunming mice infected with FM1.The results show that in contrast to the positive ribavirin, the curative effect of Pr(2) proved to be better and i.padministration was more effective than poadministration

Key words: Rare earth elements, Heteropoly blues, Synthesis, Property, Antiviral activity

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