高等学校化学学报 ›› 1999, Vol. 20 ›› Issue (4): 590.

• 研究简报 • 上一篇    下一篇

L-苏式二氢鞘氨醇的立体选择性合成

杜红旺, 陈建新, 郝俊生, 潘继刚, 夏炽中   

  1. 山西大学化学系, 太原 030006
  • 收稿日期:1998-05-25 出版日期:1999-04-24 发布日期:1999-04-24
  • 通讯作者: 夏炽中
  • 作者简介:杜红旺,男,27岁,硕士.
  • 基金资助:

    国家自然科学基金(批准号:29372060);山西省自然科学基金

Stereoselective Synthesis of Lthreodihydrosphingosines

DU Hong-Wang, CHENG Jian-Xin, HAO Jun-Sheng, PAN Ji-Gang, XIA Chi-Zhong   

  1. Department of Chemistry, Shanxi University, Taiyuan, 030006
  • Received:1998-05-25 Online:1999-04-24 Published:1999-04-24

摘要: 二氢鞘氨醇(DHS)是2-氨基-1,3-二羟基的饱和长链氨基醇化合物,是构成鞘脂类(包括鞘磷脂和糖鞘脂)的主链部分.由于鞘脂类在自然界中来源稀少,又很难得到纯品.因此,作为鞘脂类主链部分的二氢鞘氨醇的合成有重要的意义.

关键词: L-苏式二氢鞘氨醇, 立体选择性, 合成

Abstract: This paper has developed a short, practical, highly stereoselective synthetic approach to L-threo-dihydrosphingosines from L-serine. All compounds were substantiated by MS, IR, 1HNMR and elementary analysis. The spectra data of 6b were in agreement with those from literature.

Key words: Dihydrosphingosines, Stereoselective, Synthesis

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