高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (2): 228.

• 论文 • 上一篇    下一篇

3-芳基磺酰氧基(取代)异噻唑的合成及除草活性

杨小平, 李正名, 王玲秀, 李永红   

  1. 南开大学元素有机化学研究所、元素有机化学国家重点实验室, 天津, 300071
  • 收稿日期:1997-02-21 出版日期:1998-02-24 发布日期:1998-02-24
  • 通讯作者: 李正名
  • 作者简介:杨小平,男,33岁,博士,副教授,现在湘潭师范学院.

Synthesis and Herbicidal Activity of 3-Arylsulfonyloxy (substituted) isothiazoles

YANG Xiao-Ping, LI Zheng-Ming, WANG Ling-Xiu, LI Yong-Hong   

  1. Research Institute of Elemento Organic Chemistry, Key Laboratory of Elemento organic Chemistry, Nankai University, Tianjin, 300071
  • Received:1997-02-21 Online:1998-02-24 Published:1998-02-24

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被引次数

8

摘要： 通过3-羟基异噻唑和4-氰基-5-甲硫基-3-羟基异噻唑与芳基磺酰氯在碱性条件下缩合,合成了3-芳基磺酰氧基异噻唑和3-芳基磺酰氧基-4-氰基-5-甲硫基-异噻唑.对所合成的化合物进行了除草活性的测定.

关键词: 3-芳基磺酰氧基(取代)异噻唑, 合成, 除草活性

Abstract: To look for novel compounds with biological activity, 3-arylsulfonyloxy(substituted) isothiazoles were synthesized by the condensation of 3-hydroxy(substituted) isothiazoles with arylsulfonylchlorides in the presence of base. The strctures of target compounds were confirmed by elemental analysis, 1H NMR, IR, MS. Also, the single crystal structures of compounds 3c and 4b were determined. All the facts ascertained that the sulfonylization position was oxygen atom of isothiazole heterocycle. The herbicidal activities of title compounds were determined and the result showed that it was possible that they were ALS inhibitors.

Key words: 3-Arylsulfonyloxy(substituted) isothiazole, Synthesis, Herbicidal activity

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