高等学校化学学报 ›› 1997, Vol. 18 ›› Issue (1): 76.

• 研究简报 • 上一篇    下一篇

1-(取代硅基甲硫基)甲基-2,8,9-三氧杂-5-氮杂-1-硅杂双环[3.3.3]十一烷的合成与生物活性

贺峥杰, 李正名, 杨志强   

  1. 南开大学元素有机化学研究所, 天津, 300071
  • 收稿日期:1996-01-03 出版日期:1997-01-24 发布日期:1997-01-24
  • 通讯作者: 贺峥杰, 男, 29岁, 讲师.
  • 作者简介:贺峥杰, 男, 29岁, 讲师.
  • 基金资助:

    国家自然科学基金重点基金

Synthesis and Bioactivity of 1-(Substituted silylmethylthio)methyl-2, 8, 9-trioxa-5-aza-1-silabicyclo[3.3.3]undecanes

HE Zheng-Jie, LI Zheng-Ming, YANG Zhi-Qiang   

  1. Elemento-Orgamc Chemistry Institute, Nankai Uniuersity, Tianjin, 300071
  • Received:1996-01-03 Online:1997-01-24 Published:1997-01-24

关键词: 有机硅化合物, 合成, 生物活性

Abstract: By the reactlon of (substituted silyl)methanethiols with 1-chloromethyl-2, 8, 9-tri-oxa- 5-aza-1-silabicyclo [3.3, 3] undecane, eleven novel organosilicon compounds were syn-thesized.Their structures were confirmed by 1HNMR, MSand elementary analysis.Arare rearrangement breakdown pattern was found ln their mass spectra.Preliminary bioassay re-sults showed these compounds have some antitumor activity.

Key words: Organosilicon compound, Synthesis, Bioactivity

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