高等学校化学学报

高等学校化学学报 ›› 1993, Vol. 14 ›› Issue (7): 963.

• 研究简报 • 上一篇    下一篇

N,N-二(2-氯乙基)果糖基磷酰胺酯的合成及其抗肿瘤活性研究

陈茹玉, 陈小茹   

  1. 南开大学元素有机化学研究所, 天津 300071
  • 收稿日期:1992-10-12 修回日期:1993-02-17 出版日期:1993-07-24 发布日期:1993-07-24
  • 通讯作者: 陈茹玉
  • 作者简介:第一作者:女, 73岁, 博士, 教授(学部委员).
  • 基金资助:

    国家自然科学基金

Synthesis of N,N-bis(2-chloroethyl) Fructopyranosyl- phosphoramidates and Their Antitumor Activities

CHEN Ru-Yu, CHEN Xiao-Ru   

  1. Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071
  • Received:1992-10-12 Revised:1993-02-17 Online:1993-07-24 Published:1993-07-24

PDF (PC)

被引次数

22

关键词: 磷酰胺酯, 合成, 抗肿瘤活性

Abstract: In this paper, a series of new N, N-bis(2-chloroethyl) fructopyranosyl phosphoramidates were synthesized by the reaction between phosphorus oxychloride and 2,3:4,5-di-O-isopropylidene-Dructopyranse(1).The structures of all compounds prepared were determined by 1H NMR, IRand elemental analysis.The existence of diastereoisomers were proved by 31P NMR, but only one pure iso-mer was isolated by recrystallization.The results of preliminary biological tests indicated that the title compounds had the inhibition effect against L1210 cells and 5-180 tumors.

Key words: Phosphoramidate, Synthesis, Antitumor activity

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