高等学校化学学报

高等学校化学学报 ›› 1993, Vol. 14 ›› Issue (4): 512.

• 研究论文 • 上一篇    下一篇

稠杂环化合物的研究(Ⅷ)——3-(α-萘亚甲基)-6-烷基/芳基均三唑并[3,4-b]-1,3,4-噻二唑的合成及生物活性研究

张自义1,2, 李明1,2, 赵岚1,2, 李正名3, 廖仁安3   

  1. 1. 兰州大学化学系, 兰州 730000;
    2. 南开大学元素有机化学国家重点实验室, 天津 300071;
    3. 南开大学元素有机化学研究所
  • 收稿日期:1992-05-16 修回日期:1993-01-10 出版日期:1993-04-24 发布日期:1993-04-24
  • 通讯作者: 张自义
  • 基金资助:

    国家自然科学基金

Studies on Condensed Heterocyclic Compounds (Ⅷ)——Synthesis and Biological Activities of 3-(α-Naphthylmethyiene)-6-aikyl/aryl-S-triazolo[3, 4-b]-1,3,4-thiadiazoles

ZHANG Zi-Yi1,2, LI Ming1,2, ZHAO Lan1,2, LI Zheng-Ming3, LIAO Ren-An3   

  1. 1. Department of Chemistry, Lanzhou University, Lanzhou, 730000;
    2. National Key Labratory of Elemario-Organic Chemistry, Nankai Universily, Tianjin, 300071;
    3. The Research Institute of Etemeto-Organic Chemistry, Nankai Univrsity
  • Received:1992-05-16 Revised:1993-01-10 Online:1993-04-24 Published:1993-04-24

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摘要： 合成了15个新的3-(α-萘亚甲基)-6-烷基/芳基均三唑并[3,4-b]-1,3,4-噻二唑,经EA、JR、1HNMR和MS确定其组成和结构,并对其代表物4b、4d、4f和4g的抗菌、除草、植物生长调节活性进行了初步观察。

关键词: 合成, 3-(&alpha, -萘亚甲基)-6-烷基/芳基均三唑并[3, 4-b]-1, 3, 4-噻二唑, 生物活性

Abstract: Fifteen new compounds with the general formula:(这里有图片19930420-512-1.gif)in which ARis CH3, C2H5, C3H7, C4H9, C5H11, 4-XC5H4(X-H, F, Cl, Br, I, CH3, CH3O, NO2), 2-ClC6H4 3-ClC6H4 have been prepared through the cyclization of 3-(α-naphthylmethylene)-4-amino-5-mercapto-1,2, 4-triazoie(3) with aliphatic earboxyhc acids and aromatic carboxylic acids in the presence of phosphorus oxychloride.The structures of the products were proved by 1H NMR, 1R, MSand elemental analysis, it was found that some of these compounds have herbicidai and fungical activities.

Key words: Synthesis, 3-(α-Naphthyimethylene)-6-atkyl aryi-S-triazoio[3,4-b]-1,3,4-thiadiazols, Biological activities

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