高等学校化学学报

高等学校化学学报 ›› 1993, Vol. 14 ›› Issue (2): 220.

• 研究简报 • 上一篇    下一篇

2-苯基-苯并异硒唑酮-3及其衍生物的合成和抗肿瘤活性的初步研究

周志彬, 夏小平, 徐辉碧, 赵成学, 陈春英   

  1. 华中理工大学化学系, 武汉 430074
  • 收稿日期:1992-04-10 修回日期:1992-09-26 出版日期:1993-02-24 发布日期:1993-02-24
  • 通讯作者: 夏小平
  • 基金资助:

    湖北省自然科学基金

Synthesis and Anti-tumor Activity of Ebselen and Its Derivatives

ZHOU Zhi-Bin, XIA Xiao-Ping, XU Hui-Bi, ZHAO Cheng-Xue, CHEN Chun-Ying   

  1. Department of Chemistry, Hwazhong University of Science and Technology, Wuhan, 430074
  • Received:1992-04-10 Revised:1992-09-26 Online:1993-02-24 Published:1993-02-24

PDF (PC)

被引次数

4

关键词: 硒酶模型化合物, 2-苯基-苯并异硒唑酮-3, 合成, 抗肿瘤活性

Abstract: Ebselen is a organoselenium compound.It exhibits anti-tumor oxidant activity similar to that of glutathione-peroxidase(GSH-Px).In this paper, ebselen and its derivatives were synthesized using ortholithation, selenium insertion from benzanilide and its derivatives, and characterized by IR, 1H NMR,UV,MSspectrum.The results of retarding S,Mascites tumor activity of ebselen is more effective than Na2SeO3.

Key words: Selenoenzyme-like compounds, Ebselen, Synthesis, Anti-tumor activity

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