高等学校化学学报

高等学校化学学报 ›› 1993, Vol. 14 ›› Issue (10): 1399.

• 研究简报 • 上一篇    下一篇

氟尿嘧啶自旋标记衍生物的合成与抗肿瘤活性

王彦广1, 田暄2, 李景新2, 陈耀祖2   

  1. 1. 天津大学化学系, 天津 300072;
    2. 兰州大学化学系
  • 收稿日期:1993-11-19 修回日期:1993-05-06 出版日期:1993-10-24 发布日期:1993-10-24
  • 通讯作者: 王彦广, 男, 28岁, 博士, 讲师、
  • 作者简介:王彦广, 男, 28岁, 博士, 讲师、
  • 基金资助:

    国家自然科学基金

Syntheses and Antitumor Activities of New Spin-labeled 5-Fluorouracil Derivatives

WANG Yan-Guang1, TIAN Xuan2, LI Jing-Xin2, CHEN Yao-Zu2   

  1. 1. Chem.Dept., Tianjin University, Tianjin, 300072;
    2. Chem.Dept., Lanzhou University
  • Received:1993-11-19 Revised:1993-05-06 Online:1993-10-24 Published:1993-10-24

PDF (PC)

被引次数

35

关键词: 氟尿嘧啶, 自旋标记, 抗肿瘤活性, 合成

Abstract: Aseries of new spin-labeled 5-fluorouracil derivatives, as potential antitumor agents, were synthesized, and their structures were confirmed by IR, UV, MSand ESRspectra as well as elemental analysis.The antitumor activities of these compounds were tested against EACin mice.The preliminary results showed that some of the compounds exhibit certain antitumor activity.

Key words: Fluorouracil, Spin labeling, Antitumor activity, Synthesis (Ed.: J, H, A)

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