高等学校化学学报

高等学校化学学报 ›› 1991, Vol. 12 ›› Issue (6): 719.

• 论文 • 上一篇    下一篇

1-苯基-3-甲基-4-(β-苯甲酰基-乙酰基)吡唑酮-5的合成及其烯醇-酮式互变异构研究

孔碧霞, 李沅英, 杨燕生   

  1. 中山大学化学系, 510275
  • 收稿日期:1990-03-19 出版日期:1991-06-24 发布日期:1991-06-24
  • 通讯作者: 杨燕生
  • 基金资助:

    国家自然科学基金;长春应化所稀土物理与化学开放实验室资助课题

Studies on Synthesis for 1-Phenyl-3-methyl-4-(β-benzoylocetyl) pyrazolone-5 and Its Equilibrium of Keto-Enol Tautomerism

Kong Bi-xia, Li Yuan-ying, Yang Yan-sheng   

  1. Department of Chemistry, Zhongshan University, Guangzhou, 510275
  • Received:1990-03-19 Online:1991-06-24 Published:1991-06-24

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摘要： 用两步酰基化反应合成了1种新的酰代吡唑酮,即1-苯基-3-甲基-4-(β-苯甲酰基-乙酰基)吡唑酮-5(简称PMPEP),用元素分析、质谱分析确定了该化合物的组成及分子量,测定了其红外、紫外光谱及1H和13C核磁共振谱,讨论了溶液中酮式-烯醇式互变异构现象,并用单晶x射线分析确定了分子的空间分布,从而确认了上述波谱分析的结果。

关键词: 化合物, 合成, 酮-烯醇互变异构, 单晶

Abstract: Anew compound, 1-Phenyl-3-methyl-4-(β-benzoylocetyl) pyrazolone-5 was synthesized by acylation. Its composition and molecular weight were confirmed by elemental analysis and mass spectrometry. The presence of the enol-chelating form at the side chain, 4-(β-benzoyllacetyl) was indicated by IR, UV and 13C NMR, and also confirmed by X-ray crystal analysis. The equilibrium of keto-enol tautomerism for this compound was investigated by UVspetra and also by 1H NMR emphatically.

Key words: Compound, Synthesis, Keto-enol tautomcrism, Single crystal

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