In the past few decades， structural DNA nanotechnology， as a rapidly developing， controllable self- assembling strategy， enables the design and construction of a variety of sophisticated nanostructures. Particularly， DNA origami structures feature unique properties， such as rationally designed geometry， precise spatial addressabi?lity， easy of modification and good biocompatibility， which provide them with broad prospects in drug delivery. In this minireview， the research progresses of drug delivery systems based on the DNA origami technique were summarized. The future development prospects of DNA origami nanocarriers and remaining challenges in this field were also discussed.
