Gemcitabine/polypyrrole Composite Nanoparticles for Chemo-photothermal Combination Ovarian Cancer Therapy

doi:10.7503/cjcu20220345

Chem. J. Chinese Universities ›› 2022, Vol. 43 ›› Issue (8): 20220345.doi: 10.7503/cjcu20220345

• Polymer Chemistry • Previous Articles

Gemcitabine/polypyrrole Composite Nanoparticles for Chemo-photothermal Combination Ovarian Cancer Therapy

LIU Shuwei¹, JIN Hao¹, YIN Wanzhong²(), ZHANG Hao¹()

^1.Joint Laboratory of Opto?Functional Theranostics in Medicine and Chemistry，the First Hospital of Jilin University，Changchun 130021，China
^2.Department of Otorhinolaryngology，Head and Neck Surgery，the First Clinical Hospital，Norman Bethune College of Medicine of Jilin University，Changchun 130021，China

Received:2022-05-15 Online:2022-08-10 Published:2022-05-24
Contact: YIN Wanzhong,ZHANG Hao E-mail:yinwz@jlu.edu.cn;hao_zhang@jlu.edu.cn
Supported by:
the Science and Technology Development Program of Jilin Province, China(20200801025GH);the Science and Technology Project of Jilin Provincial Department of Education, China(JJKH20221079KJ);the Postdoctoral Science Foundation of China(2021TQ0125);the Industrial Technology Research and Development Project of Development and Reform Commission of Jilin Province, China(2019C049-8);the Interdisciplinary Integration and Innovation Project of Jilin University, China(JLUXKJC2021QZ10)

Abstract

Abstract:

Polypyrrole nanoparticles（NPs） were prepared through iron ion-induced oxidative poly?merization and employed for loading chemotherapy drug gemcitabine， thus producing gemcitabine/polypyrrole composite NPs. The composite NPs indicate strong loading capacity for gemcitabine and good stability in aqueous solution， which reduces the toxicity and side effects of gemcitabine on normal tissues. In addition， the composite NPs have strong absorption in the near-infrared region and can transform the absorbed light energy into heat， acting as an efficient photothermal reagent for tumor photothermal therapy. Meanwhile， the composite NPs are capable to release gemcitabine and perform photothermal-guided chemotherapy. As the reagent with chemo-photothermal combination therapeutic efficacy， gemcitabine/polypyrrole composite NPs can ablate ovarian cancer cells under near-infrared laser irradiation， showing the potential for ovarian cancer therapy.

Key words: Polypyrrole, Gemcitabine, Composite nanoparticles, Chemotherapy, Photothermal therapy

CLC Number:

O631

TrendMD:

LIU Shuwei, JIN Hao, YIN Wanzhong, ZHANG Hao. Gemcitabine/polypyrrole Composite Nanoparticles for Chemo-photothermal Combination Ovarian Cancer Therapy[J]. Chem. J. Chinese Universities, 2022, 43(8): 20220345.

Figures/Tables 10

References 21

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Gemcitabine/polypyrrole Composite Nanoparticles for Chemo-photothermal Combination Ovarian Cancer Therapy

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