Spectroelectrochemistry Studies of Antitumor Antibiotics Daunomycin

Abstract

Abstract: The electrode process of antitumor daunomycin has been investigated by using in situ spectroelectrochemical techniques, with the aid of cyclic voltammetry and infrared spectrophotometry. Possible mechanisms of its reduction processes have been discussed where the concentration makes a critical effect. When the DRNconcentration is low, two successive one electron reduction steps are demonstrated, which was followed by an aglycon elimination reaction, and then, the product 7 deoxydaunomycinone received one electron to form 7 deoxysemidaunomycione free radical, such radicals can disproportionate or associate easily. But if high, only one electron reduction happened to get the corresponding semiquinone radicals, which can also associate rapidly.

Key words: Anthracycline antibiotics, Daunomycin, Cyclic voltammetry, Spectroelectrochemistry

CLC Number:

O657

TrendMD:

QU HaiYun, CHENG GuiFang, PENG HuiQi, HE PinGang, FANG YuZhi . Spectroelectrochemistry Studies of Antitumor Antibiotics Daunomycin[J]. Chem. J. Chinese Universities, 2001, 22(12): 2000.

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Spectroelectrochemistry Studies of Antitumor Antibiotics Daunomycin

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