Chem. J. Chinese Universities

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Colorimetric Detection of cis-Pt with Gold Nanoparticle Probes

SUN Lin-Lin, LIU Dian-Jun, WANG Zhen-Xin*   

  1. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  • Received:2006-05-11 Revised:1900-01-01 Online:2007-04-10 Published:2007-04-10
  • Contact: WANG Zhen-Xin

Abstract: A novel method of colorimetric assay for determining cis-Pt (cis-diammino-dichloroplatinum Ⅱ) was found by the binding affinities between cis-Pt and DNA based on the change of surface plasmon resonance band of gold nanoparticles. The red-shift of the maximum band of the surface plasmon resonance band of gold nanoparticles increased linearly with the logarithm of the cis-Pt concentration from 40 to 2000 nmol/L and the detection limit is 40 nmol/L when the concentration of gold nanoparticles is 4 nmol/L. The colorimetric readout can be visualised with the naked eyes.

Key words: cis-Pt, Gold nanoparticle, Colorimetric assay

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