Chiral Gold Nanoprobes for Colorimetric Detection of the Drug Enantiomers

doi:10.7503/cjcu20240352

Abstract

Abstract:

Based on the good optoelectronic properties of gold nanoparticles and the good RGB sensing performance of mobile intelligent devices， a chiral colorimetric detection method for the rapid detection of R/S-phenylalamine and R/S-ibuprofen enantiomer molecules was designed. Chiral gold nanoparticles exhibit non-covalent interactions， such as electrostatic， hydrogen bonding， and hydrophilic（hydrophobic） interactions， which cause energy resonance transfer on the surface of nanomaterials， resulting in their stabilization and aggregation， and then show different colors， and finally achieving the purpose of colorimetric detection. The addition of copper ions（Cu²⁺） during the detection process can enhance chiral recognition because Cu²⁺ can form complexes with enantiomer molecules and chiral gold nanoparticles at the same time. In addition， the sensitive RGB detection performance of mobile intelligent devices was used to quantitatively detect the enantiomer molecules of R/S-phenylalamine and R/S-ibuprofen， and the detection limits were 124.35 and 104.58 μmol/L， 123.95 and 111.44 μmol/L， respectively. At the same time， the method can realize the detection of enantiomeric mixtures within a certain concentration range. In this work， chiral gold nanoparticles were used as colorimetric probes and mobile intelligent devices were used as detection devices to construct a fast and convenient detection method， which has potential application value in the detection of enantiomer molecules.

Key words: Drug enantiomer, Gold nanoparticle, Chiral recognition, Colorimetric detection, RGB detection

CLC Number:

O657

TrendMD:

TAN Xiaoping, WU Hongwei, WANG Dandan, ZHANG Jin, ZHANG Junhui. Chiral Gold Nanoprobes for Colorimetric Detection of the Drug Enantiomers[J]. Chem. J. Chinese Universities, 2025, 46(2): 20240352.

Figures/Tables 7

References 32

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Number	Amount of enantiomers in the tested solution	e. e. value of the tested solution（%）	B⁃value	RGB detection e. e.（%）
1	S⁃APP∶R⁃APP=65∶35	30.0	42	26.6
2	S⁃IBU∶R⁃IBU=65∶35	30.0	55	32.7
3	S⁃IBU∶R⁃IBU=48∶52（Real sample）	4.0	61	9.5

Number	Amount of enantiomers in the tested solution	e. e. value of the tested solution（%）	B⁃value	RGB detection e. e.（%）
1	S⁃APP∶R⁃APP=65∶35	30.0	42	26.6
2	S⁃IBU∶R⁃IBU=65∶35	30.0	55	32.7
3	S⁃IBU∶R⁃IBU=48∶52（Real sample）	4.0	61	9.5

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