Antibacterial Properties of N-halamine Modified Gold Nanoparticles

doi:10.7503/cjcu20240151

Chem. J. Chinese Universities ›› 2025, Vol. 46 ›› Issue (1): 20240151.doi: 10.7503/cjcu20240151

• Article • Previous Articles Next Articles

Antibacterial Properties of N-halamine Modified Gold Nanoparticles

SAREN Gerile¹, LIANG Jing¹, GUAN Shaoyu¹, CHANG Yujia¹, ZHANG Jiabo¹, LIANG Nan²(), KANG Jing¹(), DONG Alideertu¹

^1.College of Chemistry and Chemical Engineering，Inner Mongolia University，Engineering Research Center of Dairy Quality and Safety Control Technology，Ministry of Education，Hohhot 010021，China
^2.Thyroid Surgery Department of Jilin University Sino Japanese Friendship Hospital，Changchun 130000，China

Received:2024-03-29 Online:2025-01-10 Published:2024-06-12
Contact: KANG Jing E-mail:liangnan2006@jlu.edu.cn;111994013@imu.edu.cn
Supported by:
the Natural Science Foundation of Inner Mongolia Autonomous Region, China(2023QN02011);the Research Program of Science and Technology at Universities of Inner Mongolia Autonomous Region, China(NJZZ23091)

Abstract

Abstract:

The various types of diseases caused by pathogenic bacteria pose a constant threat to human life and health. The drug resistance of pathogenic bacteria is gradually increasing， which leads to a gradual decrease in the effectiveness of antibiotics. However， most of the current nanomaterials are mainly single-component antibacterials， whose singularity and one-sidedness hinder the comprehensive prevention and efficient control of microbial contamination. In order to prevent and curb the growth and spread of bacterial resistance， this work proposed the strategy of effectively compounding multiple antibacterial materials and constructing a multifaceted antibacterial system to achieve a multi-component synergistic bactericidal effect. In the study， a novel Au NP@pAMPS-Cl-b-PEG nano-antibacterial material was successfully developed by combining N-halamine polymer， which is an efficient bactericidal polymer， with gold nanoparticles（Au NP） possessing photothermal effect（PTT）. The antibacterial material aims to fully utilize the synergistic effect of photothermal and chemical antibacterial mechanisms to effectively inhibit bacteria and reduce the occurrence of antibiotic resistance. This research provides a new strategy for combined antibacterial therapy， which is of great theoretical significance and reference value for promoting the development and application of novel antibacterial drugs.

Key words: Antibacterial material, N-Halamine, Gold nanoparticles, Photothermal effect, Active chlorine

CLC Number:

O614

TrendMD:

SAREN Gerile, LIANG Jing, GUAN Shaoyu, CHANG Yujia, ZHANG Jiabo, LIANG Nan, KANG Jing, DONG Alideertu. Antibacterial Properties of N-halamine Modified Gold Nanoparticles[J]. Chem. J. Chinese Universities, 2025, 46(1): 20240151.

Figures/Tables 9

References 22

1	Morris A.， Kellner J. D.， Low D. E.， Curr. Opin. Microbiol.， 1998， 1， 524—529
2	Reygaert W. C.， AIMS Microbiol.， 2018， 4， 482—501
3	Sultan I.， Rahman S.， Jan A. T.， Siddiqui M. T.， Mondal A. H.， Front. Microbiol.， 2018， 9， 2066
4	Zhang M. S.， Wang L.， Jin H.， Zhan N.， Lan S. J.， Liu S. W.， Zhang H.， J. Control. Release， 2023， 358， 612—625
5	Rahman M.， Rebrov E. V.， Processes， 2014， 2， 466—493
6	Jiang J.， Ye G.， Lorandi F.， Angew. Chem. Int. Ed.， 2019， 58， 12096—12101
7	Arami H.， Kananian S.， Khalifehzadeh L.， Patel C. B.， Chang E.， Tanabe Y.， Zeng Y.， Madsen S. J.， Nat. Nanotechnol.， 2022， 17（9）， 1015—1022
8	Depciuch J.， Stec M.， Klebowski B.， Baran J.， Parlinska⁃Wojtan M.， Nanobiotechnology， 2019， 17（1）， 107
9	Wei Q.， Arami H.， Santos H. A.， Zhang H.， Li Y.， He J.， Zhong D.， Ling D.， Zhou M.， Adv. Sci.， 2021， 8（5）， 2002788
10	Tabish T. A.， Dey P.， Mosca S.， Salimi M.， Palombo F.， Matousek P.， Stone N.， Adv. Sci.， 2020， 7（15）， 1903441
11	Liu S. W.， Zhang M. G.， Jin H.， Wang Z.， Liu Y.， Zhang S. L.， Zhang H.， J. Am. Chem. Soc.， 2023， 145（1）， 160—170
12	Sun Y.， Zhang Y.， Xia Y.， Fan T.， Xue M.， Bulgan E.， Harnoode C.， Dong A.， Lwt⁃Food. Sci. Technol.， 2014， 59， 1068—1074
13	Chen W.， Zhu Y.， Zhang Z.， Chem. Eng. J.， 2020， 379， 122238
14	Su C.， Huang K.， Li H. H.， Lu Y. G.， Zheng D. L.， J. Nanomater.， 2020， 7， 1—13
15	Wilcoxon J. P.， Abrams B. L.， Chem. Soc. Re.， 2006， 35， 1162—1194
16	Barner⁃Kowollik C.， Junkers T.， J. Polym. Sci. Pol. Chem.， 2011， 49， 1293—1297
17	Zhu H.， Prince E.， Narayanan P.， Chem. Commun.， 2020， 56， 8131—8134
18	Kocer H. B.， Cerkez I.， Worley S. D.， ACS Appl. Mater. Interfaces， 2011， 3， 3189—3194
19	Armesto X. L.， Moisés C. L.， Fernández M. I.， J. Chem. Soc.， Perkin Trans.， 2001， 2， 608—612
20	Gao Y.， Song N.， Liu W.， Macromol. Biosci.， 2019， 19， 1970010
21	Song L.， Zhang W.， Chen H.， Int. J. Nanomed.， 2019， 14， 921—936
22	Xia Y.， Cheng C.， Wang R.， Polym. Chem.， 2014， 5， 5906—5919

[1]	YU Pengdong, GUAN Xinghua, WANG Dongdong, XIN Zhirong, SHI Qiang, YIN Jinghua. Preparation and Properties of Novel Optical and Thermal Dual Response Shape Memory Polymers [J]. Chem. J. Chinese Universities, 2022, 43(6): 20220085.
[2]	MENG Xiangyu, ZHAN Qi, WU Yanan, MA Xiaoshuang, JIANG Jingyi, SUN Yueming, DAI Yunqian. Photothermal Enhanced Photocatalytic Hydrogenation Performance of Au/RGO/Na₂Ti₃O₇ [J]. Chem. J. Chinese Universities, 2022, 43(3): 20210655.
[3]	WEI Hong, YANG Xiaoyu, LI Kebin, HAO Miao, FU Ran. Enhancement Effect of Low-power Ultrasound on Iopamidol Chlorination and the Degradation Pathway [J]. Chem. J. Chinese Universities, 2021, 42(6): 1863.
[4]	BAI Cuiting, YUE Renye, LUO Liegao, MA Nan. Quantitative Analysis of MicroRNA Content by Fluorescence Imaging in Cancer Cells Using Dual-color Fluorescence Nanosensor ^† [J]. Chem. J. Chinese Universities, 2020, 41(6): 1252.
[5]	WANG Tingting, LI Yuan, YANG Lili, BAO Changhao, CHENG Han. In vivo Dynamic Detection of Aloe Polysaccharides Using Carbon Fiber Microelectrodes Modified with Gold Nanoparticles ^† [J]. Chem. J. Chinese Universities, 2020, 41(1): 87.
[6]	WANG Xiaohui, WANG Kexin, LIU Junping, HONG Xia. Mesoporous-structure Enhanced Photothermal Effect of Fe₃O₄ Superparticles@mesoporous Silica [J]. Chem. J. Chinese Universities, 2019, 40(8): 1586.
[7]	ZHU Qinfu,HU Kezhen,LI Xiaojie,CHEN Mingqing. Preparation of Dendrimer-gold Nanoparticle Composites for pH Responsive Drug Delivery^† [J]. Chem. J. Chinese Universities, 2019, 40(5): 1065.
[8]	Siqi SUN,Ying WANG,Chuanyin SUN,Runwei WANG,Zhendong ZHANG,Zongtao ZHANG,Shilun QIU. Preparation and Catalytic Performance of Bowl-shaped Amphiphilic ZSM-5 Zeolites Supported Gold Nanoparticles ^† [J]. Chem. J. Chinese Universities, 2019, 40(12): 2436.
[9]	HE Caimei,ZHENG Jingyi,LI Xiaoxia. MoS₂-Gold Nanoparticles and Thionine-gold Nanoparticle Based Signal-enhanced Electrochemical Aptasensor for the Detection of 17β-Estradiol ^† [J]. Chem. J. Chinese Universities, 2019, 40(10): 2090.
[10]	YIN Maoli,WANG Yingfeng,REN Xuehong. Preparation of Modified Chitosan Antibacterial Nanospheres^† [J]. Chem. J. Chinese Universities, 2019, 40(1): 173.
[11]	FENG Wei,WANG Bowei,ZHENG Yan,JIANG Yang. Preparation and Surface-enhanced Raman Scattering(SERS) of Single Au Nanodot^† [J]. Chem. J. Chinese Universities, 2018, 39(9): 1875.
[12]	LI Aiju, WANG Yuxi, LU Shaoyong, LIU Kun. Ligand Exchange of Gold Nanoparticles with Thiol-terminated Polystyrene^† [J]. Chem. J. Chinese Universities, 2018, 39(3): 552.
[13]	WANG Li, LI Zhi, SHEN Xiaoqin, MA Nan. Programming Single Quantum Dot Valencies via DNA Caging^† [J]. Chem. J. Chinese Universities, 2018, 39(1): 32.
[14]	ZHANG Chanchan, ZHANG Fanghui, DING Lei, NI Zhenjie, JIANG Lang, DONG Huanli, ZHANG Xiaotao, LI Rongjin, HU Wenping. Organic Phototransistor Based on Surface Plasmon Resonance Effect^† [J]. Chem. J. Chinese Universities, 2018, 39(1): 102.
[15]	HUANG Haiping, YUE Yafeng, XU Liang, LÜ Lianlian, HU Yongmei. Glucose Biosensor Based on Dy₂(MoO₄)₃-AuNPs Composite Nanomaterial^† [J]. Chem. J. Chinese Universities, 2017, 38(4): 554.

Antibacterial Properties of N-halamine Modified Gold Nanoparticles

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 9

References 22

Related Articles 15

Recommended Articles

Metrics

Comments